Mauri M C, Bravin S, Fabiano L, Vanni S, Boscati L, Invernizzi G
Department of Clinical Psychiatry, University of Milan, Italy.
Encephale. 1995 Sep-Oct;21(5):555-8.
The frequency of depression was assessed in 43 chronic schizophrenic patients during an acute exacerbation phase of schizophrenia. The dexamethasone suppression test was administered to all patients. Depressive symptomatology showed a prevalence from 16.3% for moderate symptoms to 23.3% for mild ones. Depressive symptoms occurred concurrently with the psychotic picture and resolved as the psychosis remitted. Depressive symptoms were not relative to age, sex, duration of illness, DST cortisol levels, drug dosages and extrapyramidal side effects while basal cortisol levels were negatively correlated with basal Hamilton score.
在43例处于精神分裂症急性加重期的慢性精神分裂症患者中评估抑郁的发生率。对所有患者进行地塞米松抑制试验。抑郁症状的患病率为中度症状16.3%，轻度症状23.3%。抑郁症状与精神病症状同时出现，并随着精神病症状的缓解而消失。抑郁症状与年龄、性别、病程、地塞米松抑制试验皮质醇水平、药物剂量和锥体外系副作用无关，而基础皮质醇水平与基础汉密尔顿评分呈负相关。
