Departments of Dermatology Biochemistry Endocrinology, Rabta hospital, Tunis, Tunisia.
J Eur Acad Dermatol Venereol. 2011 Jun;25(6):705-9. doi: 10.1111/j.1468-3083.2010.03856.x. Epub 2010 Oct 3.
A significant association between psoriasis and the metabolic syndrome (MetS) has been frequently reported.
The aim of this study was to specify the main factors that determine the MetS in psoriatic Tunisian patients.
A case-control study has included 164 psoriatic patients and 216 controls.
The prevalence of MetS was higher in cases than in controls but without statistical differences [35.5% vs. 30.8%, odds ratio (OR): 1.39 CI: 0.88-2.18; P=0.095]. According to gender, the prevalence of MetS was significantly increased only in psoriatic women (47.4% vs. 30%, OR: 1.89, CI: 1.11-3.21; P=0.01). A multiple logistic regression, considering the effect of age, and gender, showed that the prevalence of MetS was significantly higher in cases than in controls (OR: 1.73, CI: 1.06-2.82; P=0.03). MetS components analysed seperately showed a significantly higher prevalence of decreased high-density lipoprotein cholesterol (HDLc) (60.9% vs. 35.9%, OR: 2.77, CI: 1.8-4.27, P<0.001) and for increased hypertension (50% vs. 40%, OR: 1.48, CI: 0.97-2.257, P=0.04) in psoriatic patients. According to gender, HDLc was significantly decreased in both genders (male: OR: 2.075, CI: 1.24-3.47, P=0.004; female: OR: 3.58, CI: 2.07-6.19, P<0.0001), while hypertension was increased only in psoriatic men (OR: 2.09, CI: 1.24-3.51, P=0.004) and abdominal obesity only in psoriatic women (OR: 2.31, CI: 1.30-4.11, P=0.002).
Decreased HDLc is the main biological abnormality that characterized MetS in Tunisian psoriatic patients. Moreover, contrary to men, psoriatic women have shown a significantly higher prevalence of MetS, which is, in addition to decreased HDLc, mainly attributed to abdominal obesity.
银屑病与代谢综合征（MetS）之间存在显著关联已被频繁报道。
本研究旨在明确决定突尼斯银屑病患者 MetS 的主要因素。
一项病例对照研究纳入了 164 例银屑病患者和 216 例对照。
与对照组相比，病例组中 MetS 的患病率更高，但无统计学差异[35.5%比 30.8%，比值比（OR）：1.39，95%置信区间（CI）：0.88-2.18；P=0.095]。按性别分层后，仅在女性银屑病患者中，MetS 的患病率显著增加（47.4%比 30%，OR：1.89，95%CI：1.11-3.21；P=0.01）。在考虑年龄和性别影响的多因素逻辑回归分析中，病例组中 MetS 的患病率显著高于对照组（OR：1.73，95%CI：1.06-2.82；P=0.03）。单独分析 MetS 的各项组成部分显示，在银屑病患者中，高密度脂蛋白胆固醇（HDLc）降低（60.9%比 35.9%，OR：2.77，95%CI：1.8-4.27，P<0.001）和高血压（50%比 40%，OR：1.48，95%CI：0.97-2.257，P=0.04）的患病率显著更高。按性别分层后，HDLc 在男性（OR：2.075，95%CI：1.24-3.47，P=0.004）和女性（OR：3.58，95%CI：2.07-6.19，P<0.0001）中均显著降低，而高血压仅在男性银屑病患者中增加（OR：2.09，95%CI：1.24-3.51，P=0.004），腹部肥胖仅在女性银屑病患者中增加（OR：2.31，95%CI：1.30-4.11，P=0.002）。
HDLc 降低是突尼斯银屑病患者 MetS 的主要生物学异常特征。此外，与男性银屑病患者相比，女性银屑病患者的 MetS 患病率显著更高，除了 HDLc 降低外，这主要归因于腹部肥胖。
