CNRS UMR 6061-Institut de Génétique et Développement de Rennes, 2 av du Pr. Bernard, 35000 Rennes, Université de Rennes 1, France.
Traffic. 2011 Feb;12(2):149-61. doi: 10.1111/j.1600-0854.2010.01126.x. Epub 2010 Oct 29.
The Notch signaling pathway regulates numerous aspects of metazoan development and tissue renewal. Deregulation or loss of Notch signaling is associated with a wide range of human disorders from developmental syndromes to cancer. Notch receptors and their ligands are widely expressed throughout development, yet Notch activation is robustly controlled in a spatio-temporal manner. Within the past decades, genetic screens and biochemical approaches led to the identification of more than 10 E3 ubiquitin ligases and deubiquitinating enzymes implicated in the regulation of the Notch pathway. In this review, we highlight the recent studies in Notch signaling that reveal how ubiquitination of components of the Notch pathway, ranging from degradation to regulation of membrane trafficking, impacts on the developmental control of the signaling activities of both Notch receptors and their ligands.
Notch 信号通路调控着后生动物发育和组织更新的诸多方面。 Notch 信号通路的失调或缺失与从发育综合征到癌症等多种人类疾病有关。 Notch 受体及其配体在整个发育过程中广泛表达，但 Notch 激活在时空上受到严格控制。在过去的几十年中，遗传筛选和生化方法鉴定出了 10 多种 E3 泛素连接酶和去泛素化酶，这些酶参与 Notch 途径的调控。在这篇综述中，我们强调了 Notch 信号通路的最新研究，这些研究揭示了 Notch 途径成分的泛素化（从降解到调控膜运输）如何影响 Notch 受体及其配体信号活性的发育调控。
