Department of Biological Chemistry, David Geffen School of Medicine, University of California-Los Angeles, CA 90095, USA.
Dev Cell. 2011 Jul 19;21(1):134-44. doi: 10.1016/j.devcel.2011.06.006.
In the first volume of Developmental Cell, it was reported that the classic Drosophila neurogenic gene neuralized encodes a ubiquitin ligase that monoubiquitylates the Notch ligand Delta, thus promoting Delta endocytosis. A requirement for ligand internalization by the signal-sending cell, although counterintuitive, remains to date a feature unique to Notch signaling. Ten years and many ubiquitin ligases later, we discuss sequels to these three papers with an eye toward reviewing the development of ideas for how ligand ubiquitylation and endocytosis propel Notch signaling.
在《发育细胞》的第一卷中,有报道称经典的果蝇神经发生基因 neuralized 编码一种泛素连接酶,该酶可单泛素化 Notch 配体 Delta,从而促进 Delta 的内吞作用。信号发送细胞对配体内化的需求,尽管有违直觉,但迄今为止仍是 Notch 信号传递的独特特征。十年后,出现了许多泛素连接酶,我们将结合这三篇论文讨论续集,旨在回顾配体泛素化和内化如何推动 Notch 信号传递的思想发展。