Department of Surgery, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
J Cell Mol Med. 2010 Dec;14(12):2697-701. doi: 10.1111/j.1582-4934.2010.01191.x.
With the recent substantial progress in developmental biology and cancer biology, the similarities between early embryo development and tumourigenesis, as well as the important interaction between tumours and embryos become better appreciated. In this paper, we review in detail the embryonic origin of tumour, and the similarities between early embryo development and tumourigenesis with respect to cell invasive behaviours, epigenetic regulation, gene expression, protein profiling and other important biological behaviours. Given an improved understanding of the relationship between early embryo development and tumourigenesis, now we have better and broader resources to attack cancer from the perspective of developmental biology and develop next generation of prognostic and therapeutic approaches for this devastating disease.
随着发育生物学和癌症生物学的近期重大进展，早期胚胎发育与肿瘤发生之间的相似性，以及肿瘤与胚胎之间的重要相互作用得到了更好的理解。在本文中，我们详细回顾了肿瘤的胚胎起源，以及早期胚胎发育与肿瘤发生在细胞侵袭行为、表观遗传调控、基因表达、蛋白质谱分析等重要生物学行为方面的相似性。鉴于对早期胚胎发育与肿瘤发生之间关系的认识不断提高，我们现在有了更好、更广泛的资源，可以从发育生物学的角度来攻击癌症，并为这种毁灭性疾病开发下一代预后和治疗方法。
