介绍：癌症生物标志物和生育能力。

Introduction: Cancer biomarkers and fertility.

机构信息

Center for Reconstructive Urology and Men's Health, Utah Center for Reproductive Medicine, Department of Surgery (Urology), University of Utah, Salt Lake City, Utah.

IVF Unit, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

出版信息

Fertil Steril. 2018 Jan;109(1):4-5. doi: 10.1016/j.fertnstert.2017.12.009.

DOI:10.1016/j.fertnstert.2017.12.009

PMID:29307399

Abstract

Infertility has been increasingly recognized as a possible biomarker for cancer risk. There is significant data linking these two seemingly disparate diseases in infertile men and burgeoning data linking them in infertile women. Here we investigate the possible mechanisms whereby one shared genetic or epigenetic insult could confer increased risk for both infertility and cancer.

摘要

不孕不育已逐渐被视为癌症风险的一个可能生物标志物。大量数据将这两种看似不同的疾病联系起来，在不孕男性中存在显著关联，而在不孕女性中也存在越来越多的关联。在这里，我们研究了一种共同的遗传或表观遗传损伤如何导致不孕和癌症风险增加的可能机制。