Centre de Recherche Publique-Sante/Laboratoire National de Sante, Luxembourg, Luxembourg.
Emerg Infect Dis. 2010 Nov;16(11):1724-30. doi: 10.3201/eid1611.100777.
We investigated the genetic diversity of measles virus (MV) in Nigeria (2004-2005) and the Democratic Republic of the Congo (DRC) (2002-2006). Genotype B3 strains circulating in Kinshasa, DRC, in 2002-2003 were fully replaced by genotype B2 in 2004 at the end of the second Congo war. In Nigeria (2004-2005), two genetic clusters of genotype B3, both of which were most closely related to 1 variant from 1998, were identified. Longitudinal analysis of MV strain diversity in Nigeria suggested that only a few of the previously described 1997-1998 variants had continued to circulate, but this finding was concomitant with a rapid restoration of genetic diversity, probably caused by low vaccination coverage and high birth rates. In contrast, the relatively low genetic diversity of MV in DRC and the genotype replacement in Kinshasa reflect a notable improvement in local measles control.
我们调查了尼日利亚（2004-2005 年）和刚果民主共和国（DRC）（2002-2006 年）麻疹病毒（MV）的遗传多样性。2002-2003 年在金沙萨流通的刚果民主共和国基因型 B3 株在第二次刚果战争结束的 2004 年完全被基因型 B2 取代。在尼日利亚（2004-2005 年），鉴定出了两个基因型 B3 的遗传簇，它们都与 1998 年的 1 个变体最为密切相关。对尼日利亚 MV 株多样性的纵向分析表明，只有少数先前描述的 1997-1998 年变体仍在继续传播，但这一发现与遗传多样性的迅速恢复同时发生，这可能是由于疫苗接种率低和高出生率所致。相比之下，刚果民主共和国 MV 相对较低的遗传多样性和金沙萨的基因型替代反映了当地麻疹控制的显著改善。
