[非肥胖和肥胖多囊卵巢综合征女性的葡萄糖代谢特征]
[Characteristics of glucose metabolism in non-obese and obese women with polycystic ovarian syndrome].
作者信息
Shi Yu-hua, Zhao Dong-ni, Zhao Jun-li, You Li, Liu Hong, Sun Mei, Chen Zi-jiang
机构信息
Reproductive Medicine Center of Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
出版信息
Zhonghua Fu Chan Ke Za Zhi. 2010 Aug;45(8):575-7.
OBJECTIVE
To investigate characteristics of glucose metabolism of non-obese and obese women with polycystic ovary syndrome (PCOS).
METHODS
From May 2006 to April 2009, 1928 PCOS patients treated in Reproductive Medicine Center of Shandong Provincial Hospital Affiliated to Shandong University were enrolled in this study, which were divided into 901 cases [body mass index (BMI) ≥ 25 kg/m²] in obese group and 1027 cases in non-obese (BMI < 25 kg/m(2)) group. The prevalence of type 2 diabetes mellitus (T2DM), oral glucose tolerance test, impaired fasting glucose (IFG), impaired glucose tolerance (IGT) were compared between the two groups.
RESULTS
(1) Blood glucose levels: at the time of fasting, 30, 60, 120 and 180 minutes, the levels of glucose were (5.3 ± 1.1), (9.0 ± 2.4), (9.3 ± 4.4), (7.5 ± 2.8), (5.3 ± 1.8) mmol/L in obese group and (5.0 ± 0.8), (8.4 ± 3.5), (8.0 ± 4.2), (6.5 ± 3.2), (4.9 ± 1.6) mmol/L in non-obese group, which all showed statistical difference at every time point (P < 0.01). (2)The level of insulin: at the time of fasting, 30, 60, 120 min, the level of insulin were (13 ± 7), (81 ± 51), (102 ± 65), (83 ± 63) mU/L in obese group and (8 ± 5), (57 ± 35), (62 ± 44), (46 ± 39) mU/L in non-obese group, which all showed statistical difference at every time point (P < 0.01). However, at time point of 180 minutes, the level of insulin did not exhibit significantly difference between obese and non-obese group (P > 0.05). (3) The prevalence of abnormal glucose metabolism: the rate of IFG was 4.98% (96/1928). The rate of abnormal glucose tolerance was 23.08% (445/1928). The rate of IGT were 13.05% (134/1027) in non-obese group and 24.20% (218/901) in obese group, which also showed remarkable difference (P < 0.01). The rate of T2DM were 2.53% (26/1027) in non-obese group and 7.44% (67/901) in obese group, which reached significant difference (P < 0.01).
CONCLUSION
Abnormal glucose metabolism was observed more frequently in overweight or obese PCOS women.
目的
探讨非肥胖和肥胖多囊卵巢综合征（PCOS）女性的糖代谢特征。
方法
2006年5月至2009年4月，山东大学附属山东省立医院生殖医学中心收治的1928例PCOS患者纳入本研究，分为肥胖组901例[体重指数（BMI）≥25 kg/m²]和非肥胖组1027例（BMI<25 kg/m²）。比较两组2型糖尿病（T2DM）患病率、口服葡萄糖耐量试验、空腹血糖受损（IFG）、糖耐量受损（IGT）情况。
结果
（1）血糖水平：空腹、30、60、120和180分钟时，肥胖组血糖水平分别为（5.3±1.1）、（9.0±2.4）、（9.3±4.4）、（7.5±2.8）、（5.3±1.8）mmol/L，非肥胖组分别为（5.0±0.8）、（8.4±3.5）、（8.0±4.2）、（6.5±3.2）、（4.9±1.6）mmol/L，各时间点均有统计学差异（P<0.01）。（2）胰岛素水平：空腹、30、60、120分钟时，肥胖组胰岛素水平分别为（13±7）、（81±51）、（102±65）、（83±63）mU/L，非肥胖组分别为（8±5）、（57±35）、（62±44）、（46±39）mU/L，各时间点均有统计学差异（P<0.01）。然而，180分钟时，肥胖组和非肥胖组胰岛素水平无显著差异（P>
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