生殖细胞性别决定：体细胞与生殖系的协作。
Germ cell sex determination: a collaboration between soma and germline.
机构信息
Department of Biology, Johns Hopkins University, 3400 N. Charles St., Baltimore, MD 21218, USA.
出版信息
Curr Opin Cell Biol. 2010 Dec;22(6):722-9. doi: 10.1016/j.ceb.2010.09.006. Epub 2010 Oct 26.
Abstract
Sex determination is regulated very differently in the soma vs. the germline, yet both processes are critical for the creation of the male and female gametes. In general, the soma plays an essential role in regulating sexual identity of the germline. However, in some species, such as Drosophila and mouse, the sex chromosome constitution of the germ cells makes an autonomous contribution to germline sexual development. Here we review how the soma and germline cooperate to determine germline sexual identity for some important model systems, the fly, the worm and the mouse, and discuss some of the implications of 'dual control' (soma plus germline) as compared to species where germline sex is dictated only by the surrounding soma.
摘要
性别决定在体组织和生殖系中受到非常不同的调控，但这两个过程对于雄性和雌性配子的产生都是至关重要的。一般来说，体组织在调节生殖系的性别身份方面起着至关重要的作用。然而，在一些物种中，如果蝇和小鼠，生殖细胞的性染色体组成对生殖系的性发育做出了自主贡献。在这里，我们回顾了体组织和生殖系如何为一些重要的模型系统（果蝇、线虫和小鼠）的生殖系性别身份进行合作，并讨论了与仅由周围体组织决定生殖系性别的物种相比，“双重控制”（体组织加生殖系）的一些含义。
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