Institut Curie, CNRS UMR 3215, INSERM U934, 75248 Paris cedex 05, France.
Science. 2010 Oct 29;330(6004):617-22. doi: 10.1126/science.1194776.
Transient populations of cis- and trans-acting small RNAs have recently emerged as key regulators of extensive epigenetic changes taking place during periconception, which encompasses gametogenesis, fertilization, and early zygotic development. These small RNAs are not only important to maintain genome integrity in the gametes and zygote, but they also actively contribute to assessing the compatibility of parental genomes at fertilization and to promoting long-term memory of the zygotic epigenetic landscape by affecting chromatin. Striking parallels exist in the biogenesis and modus operandi of these molecules among diverse taxa, unraveling universal themes of small-RNA-mediated epigenetic reprogramming during sexual reproduction.
顺式和反式作用的小 RNA 瞬态群体最近成为广泛发生于配子发生、受精和早期合子发育过程中的表观遗传变化的关键调控因子。这些小 RNA 不仅对维持配子和合子中的基因组完整性很重要，而且还通过影响染色质积极参与评估受精时亲本基因组的兼容性，并通过影响染色质促进合子表观遗传景观的长期记忆。在不同的分类群中，这些分子的生物发生和作用方式存在惊人的相似之处，揭示了有性生殖过程中小 RNA 介导的表观遗传重编程的普遍主题。
