Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, South Korea.
J Microbiol Biotechnol. 2010 Oct;20(10):1367-77. doi: 10.4014/jmb.1003.03020.
Scientific research regarding the use of live bacterial cells for therapeutic purposes has been rapidly growing over the years and has generated considerable interest to scientists and health professionals. Probiotics are defined as essential live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. Due to considerable beneficial health effects, these microorganisms are increasingly incorporated into the dairy products; however, many reports demonstrated their poor survival and stability. Their survival in the gastrointestinal (GI) tract is also questionable. To overcome these problems, microencapsulation techniques are currently receiving considerable attention. This review describes the importance of live probiotic bacterial microencapsulation using an alginate microparticulate system and presents the potentiality of various coating polymers such as chitosan and polylysine for improving the stability of this microencapsulation.
多年来,关于利用活菌细胞进行治疗目的的科学研究迅速发展,引起了科学家和健康专业人员的极大兴趣。益生菌被定义为必需的活菌,当以足够的量给予时,对宿主赋予健康益处。由于具有相当大的有益健康作用,这些微生物越来越多地被纳入乳制品中;然而,许多报告表明它们的生存能力和稳定性较差。它们在胃肠道(GI)中的生存能力也值得怀疑。为了克服这些问题,微胶囊化技术目前受到了相当大的关注。本综述描述了使用海藻酸钠微颗粒系统对活菌益生菌进行微胶囊化的重要性,并介绍了壳聚糖和聚赖氨酸等各种涂层聚合物提高这种微胶囊化稳定性的潜力。