Fernandez-Flores Angel, Suarez-Peñaranda Jose-Manuel
Service of Cellular Pathology, Clinica Ponferrada, Complejo Hospitalario Universitario Santiago de Compostela and from the University of Santiago de Compostela, Santiago de Compostela, Spain.
Appl Immunohistochem Mol Morphol. 2011 Mar;19(2):190-4. doi: 10.1097/PAI.0b013e3181f1ef0b.
Adenoma of the nipple is rare in men. It must be distinguished from a breast carcinoma and from Paget disease. In this sense, immunohistochemistry can be of some help. In women, for instance, immunoexpression of c-erbB-2 favors a diagnosis of Paget disease, according to some studies. Nevertheless, we have not found any studies on HER2/neu status, estrogen receptors, or progesterone receptors in nipple adenoma of male patients.
We present a case of an adenoma of the nipple in a 21-year-old man in which we carried out a wide immunohistochemical study.
The lesion did not express estrogen receptors, progesterone receptors, or androgen receptors. The HercepTest was negative. Smooth muscle Actin and p63 were remarked in the basal layer of the tumoral tubules, supporting the benignancy of the lesion.
This case of adenoma of the nipple in a male shows an immunophenotype that is similar to the ones reported in female patients.
男性乳头腺瘤罕见。它必须与乳腺癌和佩吉特病相鉴别。从这个意义上说，免疫组织化学可能会有所帮助。例如，根据一些研究，在女性中，c-erbB-2的免疫表达有利于佩吉特病的诊断。然而，我们尚未发现关于男性乳头腺瘤中HER2/neu状态、雌激素受体或孕激素受体的任何研究。
我们报告一例21岁男性乳头腺瘤病例，并对其进行了广泛的免疫组织化学研究。
该病变不表达雌激素受体、孕激素受体或雄激素受体。赫赛汀检测为阴性。肿瘤小管基底层平滑肌肌动蛋白和p63呈阳性，支持该病变为良性。
该例男性乳头腺瘤的免疫表型与女性患者报道的相似。
