Stamatiou Konstantinos, Galariotis Nikolaos, Michailidis Ioannis, Petrakopoulou Nerantzoula, Moustou Helen, Zizi-Sermpetzoglou Adamantia
Department of Urology, Tzaneio General Hospital of Pireas, Pireas, Greece.
Korean J Urol. 2010 Oct;51(10):724-8. doi: 10.4111/kju.2010.51.10.724. Epub 2010 Oct 21.
Sarcomatoid carcinoma (SC) of urinary bladder is a rare tumor exhibiting aggressive behavior. Here we are reviewing the pathologic and clinical characteristics of 4 consecutive cases of this rare tumor. Three out of 4 patients were males and one female. The median age was 72.8 years (range, 60-79 years). Patients underwent transurethral resection of bladder tumor and the diagnosis of bladder SC was established on the pathologic examination of the resected bladder tissue. Despite treatment all patients died within 22 months of the diagnosis of SC. SC of the bladder are true biphasic malignant neoplasm exhibiting morphologic and immunohistochemical evidence of epithelial and mesenchymal differentiation with the presence or absence of heterologous elements. The aggressive of the tumor precludes radical therapy whenever possible, since adjuvant therapy seems to have little effect.
膀胱肉瘤样癌（SC）是一种罕见的具有侵袭性的肿瘤。在此，我们回顾4例这种罕见肿瘤的连续病例的病理和临床特征。4例患者中3例为男性，1例为女性。中位年龄为72.8岁（范围60 - 79岁）。患者接受了经尿道膀胱肿瘤切除术，根据切除的膀胱组织病理检查确诊为膀胱SC。尽管接受了治疗，所有患者在SC诊断后的22个月内均死亡。膀胱SC是真正的双相恶性肿瘤，表现出上皮和间叶分化的形态学和免疫组化证据，有无异源性成分。肿瘤的侵袭性使得尽可能避免根治性治疗，因为辅助治疗似乎效果甚微。
