Arnold Paul Daniel, Macmaster Frank P, Hanna Gregory L, Richter Margaret A, Sicard Tricia, Burroughs Eliza, Mirza Yousha, Easter Phillip C, Rose Michelle, Kennedy James L, Rosenberg David R
Program in Genetics and Genomic Biology and Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada.
Brain Imaging Behav. 2009 Mar 1;3(1):64-76. doi: 10.1007/s11682-008-9050-3.
This pilot study was undertaken to determine if there was a significant association between specific glutamate system genes and regional volumes of interest implicated in the pathogenesis of obsessive-compulsive disorder (OCD). Volumetric magnetic resonance imaging (MRI) and genotyping of 7 polymorphisms in two genes, glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and solute linked carrier, family 1, member 1 (SLC1A1) were conducted in 31 psychotropic-naïve pediatric OCD patients. The rs1805476 variant of GRIN2B was associated with left but not right orbital frontal cortex (OFC) (p=0.04) and right but not left anterior cingulate cortex (ACC) volume (p=0.02). The SLC1A1 rs3056 variant was associated with increased total (p=0.01), left (p=0.02) and right (p=0.02) thalamic volume. These results suggest that GRIN2B and SLC1A1 may be associated with regional volumetric alterations in OFC, ACC, and thalamus in children with OCD.
本初步研究旨在确定特定谷氨酸系统基因与强迫症（OCD）发病机制中涉及的感兴趣区域体积之间是否存在显著关联。对31名未接受过精神药物治疗的儿童OCD患者进行了容积磁共振成像（MRI）以及对两个基因（离子型谷氨酸受体N-甲基-D-天冬氨酸2B型（GRIN2B）和溶质载体家族1成员1（SLC1A1））中的7个多态性进行基因分型。GRIN2B的rs1805476变体与左侧而非右侧眶额皮质（OFC）相关（p = 0.04），与右侧而非左侧前扣带回皮质（ACC）体积相关（p = 0.02）。SLC1A1的rs3056变体与丘脑总体积增加（p = 0.01）、左侧丘脑体积增加（p = 0.02）和右侧丘脑体积增加（p = 0.02）相关。这些结果表明，GRIN2B和SLC1A1可能与OCD儿童的OFC、ACC和丘脑区域体积改变有关。
