谷氨酸受体基因（GRIN2B）与儿童强迫症患者前扣带回谷氨酸能浓度降低有关。
Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.
作者信息
Arnold Paul Daniel, Macmaster Frank P, Richter Margaret A, Hanna Gregory L, Sicard Tricia, Burroughs Eliza, Mirza Yousha, Easter Phillip C, Rose Michelle, Kennedy James L, Rosenberg David R
机构信息
Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8.
出版信息
Psychiatry Res. 2009 May 15;172(2):136-9. doi: 10.1016/j.pscychresns.2009.02.005. Epub 2009 Mar 25.
Abstract
In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
摘要
在这项初步研究中，对16名未服用过精神药物的患有强迫症（OCD）的儿科患者进行了磁共振波谱（MRS）研究，并对两个谷氨酸系统基因中的六个候选多态性进行了基因分型。在离子型N-甲基-D-天冬氨酸2B型谷氨酸受体（GRIN2B）的rs1019385多态性与前扣带回皮质（ACC）谷氨酸能浓度（Glx）降低之间发现了显著关联，但与枕叶Glx无关。这些结果表明，GRIN2B可能与ACC中的Glx相关，ACC是一个一直与OCD有关的区域。
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