Rogowicz-Frontczak A, Araszkiewicz A, Pilacinski S, Zozulinska-Ziolkiewicz D, Wykretowicz A, Wierusz-Wysocka B
Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Mickiewicza 2, Poznan, Poland.
Exp Clin Endocrinol Diabetes. 2011 May;119(5):281-5. doi: 10.1055/s-0030-1267184. Epub 2010 Oct 28.
The aim of the study was to assess the factors that influence carotid intima-media thickness (CIMT) and arterial stiffness in type 1 diabetic patients.
We included 87 type 1 diabetic patients (44 women, 43 men), median age 34 years, disease duration 10 years, HbA1c 8.2%. CIMT was measured using high resolution ultrasonography. Arterial stiffness was assessed with the use of digital volume pulse analysis and tonometric measurement of wave reflection and central haemodynamics. Serum C-reactive protein (hsCRP), matrix metalloproteinase-9 (MMP-9), soluble intracellular adhesion molecule-1 (sICAM-1) and myeloperoxidase (MPO) concentrations were also measured.
CIMT and arterial stiffness correlated with age, duration of diabetes, systolic and diastolic blood pressure, GFR-glomerular filtration rate and sICAM-1. Multiple regression analysis identified only age as significant determinant of CIMT. Age, mean blood pressure and GFR, but not duration of diabetes were significant determinants of arterial stiffness.
In type 1 diabetic patients both CIMT and arterial stiffness were related to age, blood pressure, kidney function and sICAM-1 serum concentration.
本研究旨在评估影响1型糖尿病患者颈动脉内膜中层厚度（CIMT）和动脉僵硬度的因素。
我们纳入了87例1型糖尿病患者（44名女性，43名男性），中位年龄34岁，病程10年，糖化血红蛋白（HbA1c）为8.2%。使用高分辨率超声测量CIMT。通过数字容积脉搏分析以及脉搏波反射和中心血流动力学的压力测量法评估动脉僵硬度。还测量了血清C反应蛋白（hsCRP）、基质金属蛋白酶-9（MMP-9）、可溶性细胞间黏附分子-1（sICAM-1）和髓过氧化物酶（MPO）的浓度。
CIMT和动脉僵硬度与年龄、糖尿病病程、收缩压和舒张压、肾小球滤过率（GFR）以及sICAM-1相关。多元回归分析仅确定年龄是CIMT的显著决定因素。年龄、平均血压和GFR而非糖尿病病程是动脉僵硬度的显著决定因素。
在1型糖尿病患者中，CIMT和动脉僵硬度均与年龄、血压、肾功能以及sICAM-1血清浓度有关。
