Department of Diagnostic Radiology, Philipps University Marburg, University Hospital Giessen and Marburg GmbH, Marburg, Germany.
J Magn Reson Imaging. 2010 Nov;32(5):1166-71. doi: 10.1002/jmri.22355.
To compare image quality and diagnostic accuracy of 0.5 molar gadobenate dimeglumine and 1.0 molar gadobutrol in contrast-enhanced (CE) magnetic resonance angiography (MRA) of the lower extremities interindividually.
The study was approved by our Institutional Review Board. Written informed consent was obtained from all patients before enrollment in the study. We prospectively included 74 patients (21 women, 53 men; mean age ± SD: 67.9 ± 11.0 years) with suspected peripheral occlusive vascular disease. All patients underwent a contrast-enhanced MRA of both lower extremities with either 0.1 mL/kg body weight gadobutrol or gadobenate dimeglumine. Image quality, stenosis grade, and artifacts were assessed by two blinded, independent investigators. Signal intensity (SI), signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were measured by a third investigator. Contrast agent groups were compared to each other using a two-sided Student's t-test.
The results did not show significant differences for SI, SNR, or CNR. Both investigators were in significant accordance (P < 0.05) with regard to stenosis detection.
We conclude that application of standard clinical doses (0.1 mL/kg body weight) of both contrast agents provides similar diagnostic results and gadolinium dose could be reduced by the application of a single dose of gadobenate dimeglumine for CE run-off MRA.
比较 0.5 摩尔钆贝葡胺和 1.0 摩尔钆布醇在下肢对比增强磁共振血管造影（CE-MRA）中的图像质量和诊断准确性。
本研究经我院伦理委员会批准。所有患者在入组前均签署书面知情同意书。我们前瞻性纳入 74 例疑似下肢外周血管阻塞性疾病的患者（21 名女性，53 名男性；平均年龄±标准差：67.9±11.0 岁）。所有患者均接受了下肢 CE-MRA 检查，使用 0.1ml/kg 体重的钆布醇或钆贝葡胺。由两名独立的、盲法的观察者评估图像质量、狭窄程度和伪影。由第三位观察者测量信号强度（SI）、信噪比（SNR）和对比噪声比（CNR）。使用双侧 Student's t 检验比较两组造影剂。
SI、SNR 或 CNR 无显著差异。两位观察者在狭窄检测方面具有显著一致性（P<0.05）。
我们得出结论，应用标准临床剂量（0.1ml/kg 体重）的两种造影剂可提供相似的诊断结果，并且单次应用钆贝葡胺可减少钆布醇的剂量，用于 CE 流出 MRA。
