[分泌性中耳炎患儿腺样体组织中PCNA、BCL-2、CD4⁺、CD8⁺的表达]

[Expression of PCNA, BCL-2, CD4+, CD8+ in the adenoid tissues from children with secretory otitis media].

作者信息

Zhang Shujun, Zhang Yuli, Yue Zhuoli, Yin Guiru, Wang Yingchun, Li Qinghong

机构信息

Department of Otolaryngology, the Affiliated Hospital to Chengde Medical College, Chengde, 067000, China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Aug;24(16):740-2.

PMID:21033101

Abstract

OBJECTIVE

To investigate the relationship between immune status of adenoids and secretory otitis media (SOM).

METHOD

The adenoid tissue samples of 72 cases with SOM and 30 cases with adenoid hypertrophy without SOM were studied by immunohistochemical method.

RESULT

The PCNA, BCL-2, CD4+, CD8+ and CD4+ / CD8+ in SOM tissue samples were 30.85 +/- 1.73, 21.27 +/- 1.25, 41.90 +/- 9.07, 20.45 +/- 7.08 and 2.10 +/- 0.17, respectively, which were much more than that of tissue samples without SOM (25.25 +/- 1.75, 14.05 +/- 1.02, 16.30 +/- 8.21, 11.15 +/- 5.71, 1.39 +/- 0.15 respectively) (P < 0.01). The expression of CD4+ in T-lymphocyte was obviously higher than that of CD8+.

CONCLUSION

In adenoid tissues of SOM patients, the activity of T-lymphocyte subsets are increased,the adenoids are enlarged and local immunity are enhanced. Therefore,adenoidectomy should be applied in SOM patients as early as possible.

摘要

目的

探讨腺样体免疫状态与分泌性中耳炎（SOM）之间的关系。

方法

采用免疫组织化学方法研究72例SOM患者及30例无SOM的腺样体肥大患者的腺样体组织样本。

结果

SOM组织样本中PCNA、BCL-2、CD4 +、CD8 +及CD4 + / CD8 +分别为30.85±1.73、21.27±1.25、41.90±9.07、20.45±7.08及2.10±0.17，显著高于无SOM的组织样本（分别为25.25±1.75、14.05±1.02、16.30±8.21、11.15±5.71、1.39±0.15）（P < 0.01）。T淋巴细胞中CD4 +的表达明显高于CD8 +。