Chang F Y, Cheng J T, Lee F Y, Wang T F, Lai K H, Lee S D, Tsai Y T
Department of Medicine, Veterans General Hospital, Taipei, Taiwan, Republic of China.
J Gastroenterol Hepatol. 1990 May-Jun;5(3):271-6. doi: 10.1111/j.1440-1746.1990.tb01628.x.
In order to understand whether the serum pepsinogen I (PGI) levels of non-ulcer dyspepsia (NUD) patients differed from those of healthy controls and which kinds of factors might influence these levels of the former, serum PGI levels were determined by radio-immunoassay in 120 healthy controls and 361 NUD patients. The mean serum PGI level was significantly lower in NUD patients than in the controls (75.8 +/- 38.2 ng/mL versus 95.9 +/- 39.3 ng/mL; P less than 0.0001); in NUD patients, it was significantly higher in males than in females (79.6 +/- 40.4 ng/mL versus 63.2 +/- 26.4 ng/mL; P less than 0.001). However, corrected serum PGI levels according to the lean body mass disclosed no sex difference. Nevertheless, there was a weak correlation between the ages of patients and serum PGI levels (r = 0.403). The serum PGI levels in blood groups A, B, AB and O did not differ significantly. Smoking might be a decisive factor, for the mean serum PGI level was significantly higher among the smokers than among the non-smokers (86.7 +/- 44.6 ng/mL versus 70.6 +/- 33.7 ng/mL; P less than 0.001). It is concluded that the mean serum PGI level of NUD patients, while affected by sex, age, smoker status and the body size, is lower than that of the healthy controls. Without endoscopy, assay of serum PGI level has no place in the diagnosis of dyspepsia because of the wide overlapping of serum PGI levels between NUD patients and patients with other common gastric lesions.
为了解非溃疡性消化不良（NUD）患者的血清胃蛋白酶原I（PGI）水平是否与健康对照者不同，以及哪些因素可能影响前者的这些水平，采用放射免疫分析法测定了120例健康对照者和361例NUD患者的血清PGI水平。NUD患者的血清PGI平均水平显著低于对照组（75.8±38.2 ng/mL对95.9±39.3 ng/mL；P<0.0001）；在NUD患者中，男性的血清PGI水平显著高于女性（79.6±40.4 ng/mL对63.2±26.4 ng/mL；P<0.001）。然而，根据瘦体重校正后的血清PGI水平未显示出性别差异。尽管如此，患者年龄与血清PGI水平之间存在弱相关性（r = 0.403）。A、B、AB和O血型患者的血清PGI水平无显著差异。吸烟可能是一个决定性因素，因为吸烟者的血清PGI平均水平显著高于非吸烟者（86.7±44.6 ng/mL对70.6±33.7 ng/mL；P<0.001）。结论是，NUD患者的血清PGI平均水平虽受性别、年龄、吸烟状况和体型影响，但低于健康对照者。由于NUD患者与其他常见胃部病变患者的血清PGI水平广泛重叠，在没有内镜检查的情况下，血清PGI水平检测在消化不良诊断中没有意义。
