Department of Pathology, University of Vermont College of Medicine, Burlington, 05405, USA.
Annu Rev Physiol. 2011;73:527-45. doi: 10.1146/annurev-physiol-012110-142305.
This review focuses on the role of the venous valves in the genesis of thrombus formation in venous thromboembolic disease (VTE). Clinical VTE and the evidence for the valvular origin of venous thrombosis are reviewed. Virchow's triad is then used as a framework for discussion to approach the question posed regarding the link between venous valvular stasis-associated hypoxia and thrombosis. Thus, the effects of blood flow stasis, hypercoagulability of blood, and the characteristics of the vessel wall within the venous valvular sinus are assessed in turn.
本篇综述重点探讨了静脉瓣膜在静脉血栓栓塞性疾病（VTE）中血栓形成中的作用。我们回顾了临床 VTE 以及静脉血栓形成与瓣膜起源相关的证据。然后，我们使用Virchow 三联征作为讨论框架，探讨了静脉瓣膜淤滞相关缺氧与血栓形成之间联系的问题。因此，我们依次评估了血流淤滞、血液高凝状态以及静脉瓣膜窦内血管壁特征的影响。
