López José A, Chen Junmei
Puget Sound Blood Center and University of Washington, Seattle, USA.
Thromb Res. 2009;123 Suppl 4:S30-4. doi: 10.1016/S0049-3848(09)70140-9.
Using Virchow's triad as framework, it is clear that alterations in any of its components (blood composition, the vessel wall, and blood flow) can influence the propensity for the development of venous thromboembolism. Each can also influence the others in ways that enhance or reduce thrombotic propensity. While past work has concentrated on blood components that influence thrombogenicity, their influences generally are manifest only after the thrombotic process has begun, and it is initiation of thrombosis on the vessel wall that is the least well understood. This brief review attempts to link risk factors such as stasis and cancer to the mechanisms that initiate thrombosis.
以魏尔啸三要素为框架，显然其任何一个组成部分（血液成分、血管壁和血流）的改变都可能影响静脉血栓栓塞形成的倾向。每一个组成部分也会以增强或降低血栓形成倾向的方式影响其他部分。虽然过去的研究主要集中在影响血栓形成的血液成分上，但它们的影响通常只有在血栓形成过程开始后才会显现出来，而血管壁上血栓形成的起始过程是最不为人所了解的。这篇简短的综述试图将诸如血流淤滞和癌症等危险因素与引发血栓形成的机制联系起来。
