Genentech Research and Early Development, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.
Curr Drug Deliv. 2011 Jan;8(1):70-8. doi: 10.2174/156720111793663589.
ImmunoPET is a non-invasive imaging technology based on tracking and quantification of radiolabeled monoclonal antibodies, antibody fragments and peptides in vivo. The knowledge of distribution and expression levels of a given receptor is a key for successful receptor targeted cancer therapy. ImmunoPET performed with probes with high affinity and specificity to a given receptor aspires to be a method for obtaining comprehensive information about current in vivo status of the targeted receptor. This review describes methods for radiolabeling of peptides, monoclonal antibodies, and antibody fragments for immunoPET and highlights the recently reported pre-clinical and clinical applications of immunoPET in receptor targeted therapy.
免疫 PET 是一种基于放射性标记的单克隆抗体、抗体片段和肽在体内的追踪和定量的非侵入性成像技术。了解特定受体的分布和表达水平是成功进行受体靶向癌症治疗的关键。使用对特定受体具有高亲和力和特异性的探针进行免疫 PET，旨在成为一种获取关于目标受体当前体内状态的综合信息的方法。本文综述了用于免疫 PET 的肽、单克隆抗体和抗体片段的放射性标记方法，并重点介绍了最近报道的免疫 PET 在受体靶向治疗中的临床前和临床应用。
