Bredell Marius G
Department of Craniomaxillofacial Surgery, University Hospital of Zürich, Zürich, Switzerland.
Head Neck Oncol. 2010 Oct 30;2:31. doi: 10.1186/1758-3284-2-31.
Sentinel lymph node (SLN) detection and biopsy is gaining popularity in the treatment of Head and Neck cancer. Various methods in this regard have been described, each with their respective advantages and disadvantages. The aim of this paper was to evaluate the potential application of Indocyanin Green (ICG) in the mapping and detection of sentinel lymph nodes (SLN) in cancers of the head and neck.
Patients with oropharyngeal cancer and N0 neck who were scheduled for primary tumor ablation as well as a neck dissection were selected. One milliliter of Indocyanin green was injected around the tumor and the sentinel node detection was performed by aiming the infra red video camera on the cervical area. When no detection was possible transcutaneously, a cervical incision was made, a sub-platysmal flap raised and further detection was done to visualize the fluorescing lymph nodes.
Detection of cervical SLN was only possible when 5 mm or less tissue covered the sentinel lymph node. Accurate and clear detection of the lymph drainage pattern and SLN was possible. There is some uptake in other tissues such as the submandibular gland which is easily distinguishable from lymphatic tissue.
Indocyanin green fluorescence is a potential valuable potential tool in the detection of SLN in patients with oropharyngeal cancer which warrants further investigation.
前哨淋巴结（SLN）检测与活检在头颈癌治疗中越来越受欢迎。关于这方面的各种方法已被描述，每种方法都有其各自的优缺点。本文的目的是评估吲哚菁绿（ICG）在头颈癌前哨淋巴结（SLN）的定位和检测中的潜在应用。
选择计划进行原发性肿瘤切除以及颈部清扫术的口咽癌且颈部N0的患者。在肿瘤周围注射1毫升吲哚菁绿，并通过将红外摄像机对准颈部区域来进行前哨淋巴结检测。当经皮无法检测到时，进行颈部切口，掀起颈阔肌下皮瓣并进一步检测以可视化荧光淋巴结。
只有当5毫米或更少的组织覆盖前哨淋巴结时，才能检测到颈部SLN。准确清晰地检测淋巴引流模式和SLN是可能的。在其他组织如颌下腺中也有一些摄取，这很容易与淋巴组织区分开来。
吲哚菁绿荧光是检测口咽癌患者SLN的一种潜在有价值的工具，值得进一步研究。
