Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (CSIC), Eduardo Cabello 6, 36208, Vigo, Spain.
Dev Comp Immunol. 2011 Mar;35(3):334-44. doi: 10.1016/j.dci.2010.10.007. Epub 2010 Nov 19.
In this paper, we describe sequences of fibrinogen-related proteins (FREPs) in the Mediterranean mussel Mytilus galloprovincialis (MuFREPs) with the fibrinogen domain probably involved in the antigen recognition, but without the additional collagen-like domain of ficolins, molecules responsible for complement activation by the lectin pathway. Although they do not seem to be true or primive ficolins since the phylogenetic analysis are not conclusive enough, their expression is increased after bacterial infection or PAMPs treatment and they present opsonic activities similar to mammalian ficolins. The most remarkable aspect of these sequences was the existence of a very diverse set of FREP sequences among and within individuals (different mussels do not share any identical sequence) which parallels the extraordinary complexity of the immune system, suggesting the existence of a primitive system with a potential capacity to recognize and eliminate different kind of pathogens.
在本文中，我们描述了来自地中海贻贝（Mytilus galloprovincialis）的纤维蛋白原相关蛋白（FREP）序列（MuFREPs），其中纤维蛋白原结构域可能参与抗原识别，但不具有纤维胶凝素的额外胶原样结构域，而纤维胶凝素分子负责通过凝集素途径激活补体。尽管它们似乎不是真正或原始的纤维胶凝素，因为系统发育分析还不够明确，但它们在细菌感染或 PAMP 处理后表达增加，并且具有类似于哺乳动物纤维胶凝素的调理活性。这些序列最显著的特点是个体之间和个体内部存在着非常多样化的 FREP 序列（不同的贻贝没有任何相同的序列），这与免疫系统的非凡复杂性相平行，表明存在一种原始的系统，具有识别和消除不同类型病原体的潜在能力。
