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白细胞介素-17 的进化和多样性突显了海洋无脊椎动物的扩张及其在黏膜免疫中的保守作用。

The Evolution and Diversity of Interleukin-17 Highlight an Expansion in Marine Invertebrates and Its Conserved Role in Mucosal Immunity.

机构信息

Institute of Marine Research (IIM), National Research Council (CSIC), Vigo, Spain.

Department of Biology, University of Padova, Padova, Italy.

出版信息

Front Immunol. 2021 Jul 27;12:692997. doi: 10.3389/fimmu.2021.692997. eCollection 2021.

DOI:10.3389/fimmu.2021.692997
PMID:34386003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8353272/
Abstract

The interleukin-17 (IL-17) family consists of proinflammatory cytokines conserved during evolution. A comparative genomics approach was applied to examine IL-17 throughout evolution from poriferans to higher vertebrates. Cnidaria was highlighted as the most ancient diverged phylum, and several evolutionary patterns were revealed. Large expansions of the IL-17 repertoire were observed in marine molluscs and echinoderm species. We further studied this expansion in filter-fed , which is a bivalve with a highly effective innate immune system supported by a variable pangenome. We recovered 379 unique IL-17 sequences and 96 receptors from individual genomes that were classified into 23 and 6 isoforms after phylogenetic analyses. Mussel IL-17 isoforms were conserved among individuals and shared between closely related Mytilidae species. Certain isoforms were specifically implicated in the response to a waterborne infection with in mussel gills. The involvement of IL-17 in mucosal immune responses could be conserved in higher vertebrates from these ancestral lineages.

摘要

白细胞介素-17 (IL-17) 家族由进化过程中保守的促炎细胞因子组成。采用比较基因组学方法研究了从多孔动物到高等脊椎动物的进化过程中的 IL-17。刺胞动物被突出为最古老的分化门，揭示了几种进化模式。海洋软体动物和棘皮动物物种中观察到 IL-17 库的大量扩增。我们进一步研究了这种扩张，它是一种滤食性双壳类动物，具有高度有效的先天免疫系统，由一个可变的泛基因组支持。我们从个体基因组中回收了 379 个独特的 IL-17 序列和 96 个受体，经过系统发育分析后分为 23 个和 6 个同工型。贻贝的 IL-17 同工型在个体之间和密切相关的贻贝类物种之间是保守的。某些同工型在贻贝鳃中对水传播感染的反应中特别涉及。这些祖先谱系中的 IL-17 可能在高等脊椎动物中参与黏膜免疫反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/3d5238038e23/fimmu-12-692997-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/e4a949a0a075/fimmu-12-692997-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/3d5238038e23/fimmu-12-692997-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/cfd3acd6e5ab/fimmu-12-692997-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/24bfae9ce09f/fimmu-12-692997-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/10bce42ca17e/fimmu-12-692997-g003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/b4565f662cd1/fimmu-12-692997-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/e4a949a0a075/fimmu-12-692997-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa27/8353272/3d5238038e23/fimmu-12-692997-g007.jpg

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