Simón Mercedes de, Sabaté Sara, Cristina Osanz Ana, Bartolomé Rosa, Dolores Ferrer Maria
Servicio de Microbiología, Laboratori de L'Agència de Salut Pública de Barcelona, Barcelona, España.
Enferm Infecc Microbiol Clin. 2010 Dec;28(10):713-5. doi: 10.1016/j.eimc.2010.04.009. Epub 2010 Oct 28.
The aim of this study was to describe the investigation of a case of meningitis in a neonatal intensive care unit in order to identify the source of infection and the associated risk factors.
An analysis was carried out on the possible risk factors associated with the infection. E. sakazakii was detected in the batch of the powdered infant formula used during the feeding of the neonate and the initial level of contamination of the microorganism was estimated. The strains of E. sakazakii previously isolated in blood and faeces of the infected neonate and those isolated in infant formula were characterised by biotype, pulsotype and antimicrobial susceptibility.
E. sakazakii was detected in one opened and two unopened cases of a single batch of powdered infant formula. The E. sakazakii strains isolated in the samples of the product and those isolated in the infected neonate showed the same biochemical, antibiotic susceptibility and PFGE pattern.
The case of meningitis in the neonatal intensive care unit occurred as a result of the use of a powered infant formula contaminated with E. sakazakii at manufacturing level, and an inadequate preparation and storing of the reconstituted product were identified as risk factors.
本研究旨在描述对新生儿重症监护病房中一例脑膜炎病例的调查，以确定感染源及相关危险因素。
对与感染相关的可能危险因素进行了分析。在新生儿喂养期间使用的一批粉状婴儿配方奶粉中检测到阪崎肠杆菌，并估算了该微生物的初始污染水平。对先前从感染新生儿的血液和粪便中分离出的阪崎肠杆菌菌株以及从婴儿配方奶粉中分离出的菌株进行了生物型、脉冲型和抗菌药敏特性分析。
在一批粉状婴儿配方奶粉的一个已开封和两个未开封包装中检测到阪崎肠杆菌。从产品样本中分离出的阪崎肠杆菌菌株与从感染新生儿中分离出的菌株具有相同的生化特性、抗生素敏感性和脉冲场凝胶电泳图谱。
新生儿重症监护病房中的脑膜炎病例是由于使用了在生产环节被阪崎肠杆菌污染的粉状婴儿配方奶粉所致，且重构产品的制备和储存不当被确定为危险因素。
