National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
Seizure. 2011 Jan;20(1):34-7. doi: 10.1016/j.seizure.2010.10.002. Epub 2010 Oct 29.
The long-term effects of vagus nerve stimulation (VNS) on seizure frequency were studied in 50 patients with epilepsy and learning disabilities. Mean observation time was 4.6 years. At follow-up, none of the patients was seizure-free, 25% had more than 50% seizure reduction, and 46% had some seizure reduction, but less than 50%. The discontinuation rate was 18%. Our results indicate that, like antiepileptic drugs, VNS does not have such a good seizure-reducing effect in patients with epilepsy and learning disabilities compared with the general epilepsy population.
研究了 50 例患有癫痫和学习障碍的患者中迷走神经刺激 (VNS) 对癫痫发作频率的长期影响。平均观察时间为 4.6 年。随访时，无患者无癫痫发作，25%的患者癫痫发作减少超过 50%，46%的患者癫痫发作减少，但少于 50%。停药率为 18%。我们的结果表明，与一般癫痫人群相比，VNS 像抗癫痫药物一样，对患有癫痫和学习障碍的患者并没有如此好的减少癫痫发作的效果。
