一只猫患有伴有白血病进展的骨髓瘤相关疾病。
Myeloma-related disorder with leukaemic progression in a cat.
作者信息
Takeuchi Yoshinori, Iizuka Haruna, Kanemitsu Hiroyuki, Fujino Yasuhito, Nakashima Ko, Uchida Kazuyuki, Ohno Koichi, Nakayama Hiroyuki, Tsujimoto Hajime
机构信息
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
出版信息
J Feline Med Surg. 2010 Dec;12(12):982-7. doi: 10.1016/j.jfms.2010.07.018. Epub 2010 Oct 30.
A 10-year-old American Shorthair cat with nasal discharge, anorexia, and weight loss was found to have pancytopenia and hyperproteinaemia. Bone marrow aspiration revealed atypical plasma cells that totalled 50% of the nucleated bone marrow cells. The number of atypical plasma cells progressively increased in the peripheral blood during the observation period of 64 days. The cat did not respond to treatments with melphalan, chlorambucil, and prednisolone, and died 71 days after the initial presentation. Clinical, cytological, histopathological, and immunohistochemical findings in this case supported the diagnosis of myeloma-related disorder (MRD) with leukaemic progression.
一只10岁的美国短毛猫出现鼻分泌物、厌食和体重减轻症状，被发现患有全血细胞减少症和高蛋白血症。骨髓穿刺显示非典型浆细胞占骨髓有核细胞总数的50%。在64天的观察期内，外周血中非典型浆细胞数量逐渐增加。这只猫对美法仑、苯丁酸氮芥和泼尼松龙治疗无反应，在首次出现症状71天后死亡。该病例的临床、细胞学、组织病理学和免疫组化结果支持伴有白血病进展的骨髓瘤相关疾病（MRD）的诊断。
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