N末端脑钠肽前体（NT-proBNP）检测无法可靠地识别缅因猫的亚临床肥厚型心肌病。
NT-proBNP measurement fails to reliably identify subclinical hypertrophic cardiomyopathy in Maine Coon cats.
作者信息
Singh Manreet K, Cocchiaro Michael F, Kittleson Mark D
机构信息
Veterinary Medical Teaching Hospital, University of California, Davis, One Shields Avenue, Davis, CA, USA.
出版信息
J Feline Med Surg. 2010 Dec;12(12):942-7. doi: 10.1016/j.jfms.2010.08.004. Epub 2010 Oct 29.
The purpose of this study was to evaluate the value of measuring plasma NT-proBNP concentration as a screening tool in cats with varying severity of subclinical hypertrophic cardiomyopathy (HCM). Plasma NT-proBNP concentration was measured in 35 cats that had previously been classified as normal, equivocal, moderate HCM or severe HCM via echocardiography. No cat had ever been in congestive heart failure. Cats with severe HCM had a significantly higher NT-proBNP concentration compared to the other groups (P<0.0003), however, the sensitivity of NT-proBNP for diagnosing cats with severe disease was only 44% (cutoff≤100pmol/l) to 55% (cutoff≤40pmol/l). There was no significant difference in NT-proBNP concentration between normal, equivocal and moderate categories (sensitivity for detecting moderate HCM was 0%). Based on the results of this study, NT-proBNP concentration is not considered adequate as a screening test for detecting mild to moderate HCM in Maine Coon cats and it appears that it may miss many cats with severe HCM.
本研究的目的是评估测量血浆N末端B型利钠肽原（NT-proBNP）浓度作为亚临床肥厚型心肌病（HCM）严重程度不同的猫的筛查工具的价值。对35只猫测量了血浆NT-proBNP浓度，这些猫先前通过超声心动图被分类为正常、疑似、中度HCM或重度HCM。没有猫曾患充血性心力衰竭。与其他组相比，重度HCM的猫的NT-proBNP浓度显著更高（P<0.0003），然而，NT-proBNP诊断重症猫的敏感性仅为44%（临界值≤100pmol/l）至55%（临界值≤40pmol/l）。正常、疑似和中度类别之间的NT-proBNP浓度没有显著差异（检测中度HCM的敏感性为0%）。基于本研究结果，NT-proBNP浓度不被认为足以作为缅因猫轻度至中度HCM的筛查试验，并且似乎可能会遗漏许多重度HCM的猫。
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