de Lima Gabriela Vieira, Ferreira Felipp da Silveira
Cardiology Service from the Pet du Bosque Veterinary Clinic, Cuiabá, Mato Grosso, Brazil.
Department of Veterinary Cardiology of the Qualittas Postgraduate Institute, Campinas, São Paulo, Brazil.
Vet World. 2017 Sep;10(9):1072-1082. doi: 10.14202/vetworld.2017.1072-1082. Epub 2017 Sep 18.
Biomarkers are quantitative indicators of biological processes performed by an organ or system. In recent years, natriuretic peptides (NPs) have emerged as important tools in the diagnosis and therapeutic monitoring of heart diseases. Research has shown that serum and plasma levels of N-terminal pro brain NP (NT-proBNP) in dogs and cats are the only biomarkers that afford to diagnose and monitor congestive processes and, indirectly, the myocardial function of small animals. The present review discusses the peer-reviewed specialized literature about NT-proBNP and presents and compares the potential clinical applications of this NP in veterinary medicine of small animals, considering diagnosis, follow-up, and prognosis of myocardial or systemic diseases. The relevance of NT-proBNP is associated with sample stability, easy determination in laboratory, sensitivity, accuracy, and the possibility to analyze myocardial function. These advantages are specially important when NT-proBNP is compared with other cardiac biomarkers, mostly those that indicate the integrity of the myocardial cell. Fast NT-proBNP assays are marketed today and may be used in association with complementary tests. Together, these methods are an important source of information in differential diagnosis of heart and lung diseases as well in the early diagnosis of cardiopathy in dogs and cats, proving valuable tools in treatment and prognosis.
生物标志物是器官或系统所执行生物过程的定量指标。近年来，利钠肽（NPs）已成为心脏病诊断和治疗监测的重要工具。研究表明，犬猫血清和血浆中的N末端脑钠肽前体（NT-proBNP）水平是仅有的可用于诊断和监测充血过程以及间接评估小动物心肌功能的生物标志物。本综述讨论了关于NT-proBNP的同行评审专业文献，并介绍和比较了这种利钠肽在小动物兽医学中的潜在临床应用，涉及心肌或全身性疾病的诊断、随访及预后。NT-proBNP的相关性与样本稳定性、实验室易于测定、敏感性、准确性以及分析心肌功能的可能性有关。当将NT-proBNP与其他心脏生物标志物（主要是那些指示心肌细胞完整性的标志物）进行比较时，这些优势尤为重要。快速NT-proBNP检测方法目前已上市，可与补充检测联合使用。这些方法共同构成了心肺疾病鉴别诊断以及犬猫心脏病早期诊断的重要信息来源，是治疗和预后的宝贵工具。
