Intensive Care Unit, Epworth Hospital, 89 Bridge Road, Richmond, Victoria 3121, Australia.
Heart Lung Circ. 2011 Oct;20(10):669-70. doi: 10.1016/j.hlc.2010.10.001. Epub 2010 Oct 30.
Chlorhexidine, a bisbiguanide, is widely used as an antiseptic agent in medical practice as it has the greatest residual antimicrobial activity. Central venous catheters coated extraluminally with chlorhexidine have been made to reduce extraluminal contamination. By using both the chlorhexidine-alchohol skin preparation and antimicrobial-coated catheters during vascular cannulation, it can reduce catheter related bloodstream significantly [1]. The reduction in infection rate is especially vital in critically ill patients who require long-term vascular access. Adverse reactions to chlorhexidine are rare and uncommon, and have been under-recognised as a cause of anaphylaxis. There are several reports of allergic reactions following exposure to chlorhexidine. We report of a case of anaphylaxis shock requiring cardiopulmonary resuscitation during the placement of a chlorhexidine impregnated central venous catheters.
洗必泰，一种双胍类化合物，由于具有最大的残留抗菌活性，因此在医学实践中被广泛用作防腐剂。已经制造出在管腔外涂有洗必泰的中心静脉导管，以减少管腔外污染。通过在血管插管过程中同时使用洗必泰-酒精皮肤制剂和抗菌涂层导管，可以显著减少导管相关的血流感染[1]。在需要长期血管通路的危重病患者中，感染率的降低尤为重要。对洗必泰的不良反应很少见且不常见，并且作为过敏反应的原因未被充分认识。有几例在接触洗必泰后发生过敏反应的报道。我们报告了一例在放置洗必泰浸渍的中心静脉导管时发生过敏反应性休克需要心肺复苏的病例。
