Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan.
Anticancer Res. 2010 Oct;30(10):3939-44.
Induction of angiogenic responses by multiple factors, a crucial step in tumor growth and metastasis, is not completely understood. Recently, involvement of the cytoskeletal actin-binding proteins in angiogenesis has been suggested as a target for anti-neovascular cancer therapy in vitro. In this study, the expression of filamin A (FLNA) and vascular endothelial growth factor (VEGF) in paraffin-embedded tumor samples from patients with well-characterized lung tumors was immunohistochemically analyzed and compared with clinical variables and survival outcome. A positive expression of FLNA and VEGF was detected in the cytoplasm of tumor cells in 66 (48.2%) and 69 (50.4%) of the 137 patients with lung cancer, respectively (p<0.0001). A significant difference was observed between FLNA expression and VEGF expression. Although our findings do not suggest that the expression of FLNA alone plays an independent prognostic role, the angiogenesis pathway mediated by FLNA appears to be responsible for controlling the growth of lung tumors.
多种因素诱导的血管生成反应是肿瘤生长和转移的关键步骤，但目前尚不完全清楚。最近，细胞骨架肌动蛋白结合蛋白在血管生成中的作用已被提出作为体外抗新生血管癌症治疗的靶点。在这项研究中，对来自具有明确特征的肺癌患者的石蜡包埋肿瘤样本中的细丝蛋白 A (FLNA) 和血管内皮生长因子 (VEGF) 的表达进行了免疫组织化学分析，并与临床变量和生存结果进行了比较。在 137 例肺癌患者中，分别有 66 例（48.2%）和 69 例（50.4%）的肿瘤细胞细胞质中检测到 FLNA 和 VEGF 的阳性表达（p<0.0001）。FLNA 表达与 VEGF 表达之间存在显著差异。尽管我们的研究结果并不表明 FLNA 的表达单独起独立的预后作用，但由 FLNA 介导的血管生成途径似乎负责控制肺肿瘤的生长。
