Walter Reed Project/Kenya Medical Research Institute, Kisumu, Kenya.
Am J Trop Med Hyg. 2010 Nov;83(5):1010-3. doi: 10.4269/ajtmh.2010.10-0174.
A cross-sectional study was performed in children 5 through 10 years of age presenting to outpatient clinics in Nyanza Province, Kenya, in which nasal swab and blood specimens were collected during the high malaria transmission season. Patients presenting with malaria-like symptoms within 4 days of fever onset were enrolled in the study. Plasmodium parasitemia was determined by blood smear microscopy. Nasal swabs were screened for a panel of respiratory viruses by polymerase chain reaction. Influenza A, rhinoviruses, and other respiratory viruses were detected in 18%, 26%, and 12% of 197 specimens, respectively. Four of 36 patients with influenza A had a positive malaria blood slide, compared with 20 of 52 patients with rhinovirus. A significant burden of disease caused by influenza A in febrile children during the study period was observed, highlighting the need for further research into the burden of influenza disease in regions where malaria is holoendemic.
一项横断面研究在肯尼亚尼安萨省的门诊诊所中对 5 至 10 岁的儿童进行，在疟疾高发传播季节采集鼻拭子和血液样本。在发热后 4 天内出现类似疟疾症状的患者被纳入研究。通过血涂片显微镜检查确定疟原虫寄生虫血症。通过聚合酶链反应对鼻拭子进行呼吸道病毒检测。在 197 份标本中，分别检测到甲型流感、鼻病毒和其他呼吸道病毒的比例为 18%、26%和 12%。在 36 例甲型流感患者中，有 4 例疟疾血片阳性，而在 52 例鼻病毒患者中，有 20 例阳性。在研究期间，发热儿童中由甲型流感引起的疾病负担明显，这突出表明需要进一步研究在疟疾呈全流行地区流感疾病的负担。
