Department of Epidemiology and Biostatistics, University of Florida, Gainesville, Florida 32610, USA.
Am J Trop Med Hyg. 2010 Nov;83(5):1133-6. doi: 10.4269/ajtmh.2010.09-0717.
Prognosis varies among persons with West Nile virus (WNV) infection, but the most important factors associated with persistent symptoms are not clear. In this cross-sectional study, 265 persons with symptomatic WNV infection during 2006-2008 completed a survey a mean of 7.7 months after diagnosis. We determined the association of demographic and clinical characteristics to the most common symptoms. Of 214 persons infected ≥ 6 months, 53% reported one or more persistent symptoms, including fatigue, muscle aches, decreased activity, difficulty with memory, and difficulty concentrating. Persons with neuroinvasive disease, hypertension, or diabetes were significantly more likely to report persistent symptoms, whereas age, sex, and time since infection were not associated with persistent symptoms. In conclusion, persistent symptoms persisted in most persons for more than six months after symptomatic WNV infection. Improved strategies for prevention and treatment are needed.
预后因西尼罗河病毒（WNV）感染者而异，但与持续症状相关的最重要因素尚不清楚。在这项横断面研究中，265 名在 2006 年至 2008 年期间患有症状性 WNV 感染的患者在诊断后平均 7.7 个月完成了一项调查。我们确定了人口统计学和临床特征与最常见症状的关联。在 214 名感染≥6 个月的患者中，53%报告了一种或多种持续症状，包括疲劳、肌肉疼痛、活动减少、记忆力减退和注意力不集中。患有神经侵袭性疾病、高血压或糖尿病的患者报告持续症状的可能性显著更高，而年龄、性别和感染后时间与持续症状无关。总之，在症状性 WNV 感染后 6 个月以上，大多数患者仍存在持续症状。需要改进预防和治疗策略。
