Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30302, USA.
Learn Mem. 2010 Oct 29;17(11):577-81. doi: 10.1101/lm.1908310. Print 2010 Nov.
Rapamycin, an inhibitor of the mammalian target of rapamycin (mTOR) kinase, has attracted interest as a possible prophylactic for post-traumatic stress disorder (PTSD)-associated fear memories. We report here that although rapamycin (40 mg/kg, i.p.) disrupted the consolidation and reconsolidation of fear-potentiated startle paradigm to a shock-paired context, it did not disrupt startle increases to a 4-sec odor cue, even though post-training increases in amygdala mTOR activity were prevented by rapamycin (also 40 mg/kg, i.p.). Thus, while rapamycin may prove useful in retarding the development of some PTSD-associated memories, its relative ineffectiveness against cued fear memories may limit its clinical usefulness.
雷帕霉素是哺乳动物雷帕霉素靶蛋白（mTOR）激酶的抑制剂，作为一种可能的创伤后应激障碍（PTSD）相关恐惧记忆的预防药物引起了关注。我们在这里报告，尽管雷帕霉素（40mg/kg，腹腔注射）破坏了与电击配对的环境中恐惧增强的惊跳反应的巩固和再巩固，但它并没有破坏对 4 秒气味线索的惊跳反应增加，即使雷帕霉素（同样为 40mg/kg，腹腔注射）也阻止了杏仁核 mTOR 活性的训练后增加。因此，虽然雷帕霉素可能对延缓某些 PTSD 相关记忆的发展有用，但它对提示性恐惧记忆的相对无效性可能限制其临床应用。
