Lozoya X, Becerril G, Martínez M
Unidad de Investigación en Medicina Tradicional y Desarrollo de Medicamentos, IMSS.
Arch Invest Med (Mex). 1990 Apr-Jun;21(2):155-62.
An experimental in vitro model was developed for the study of plant extracts reported by traditional medicines in the treatment of diarrhea. The guinea-pig isolated ileum is perfused with the plant extract using an intraluminal approach. The peristaltic reflex is induced by electrical stimulation while the plant extract is perfused. The spasmolytic effects of Psidium guajava leaf methanol, hexane and water extracts were demonstrated suggesting the existence of two different types of active components. The results obtained allow to propose this in vitro method as a useful model to reproduce some of the characteristics of the oral way of administration of plant extracts.
开发了一种体外实验模型，用于研究传统医学中报道的植物提取物治疗腹泻的效果。采用腔内给药法，用植物提取物灌注豚鼠离体回肠。在灌注植物提取物时，通过电刺激诱发蠕动反射。番石榴叶甲醇提取物、己烷提取物和水提取物均显示出解痉作用，这表明存在两种不同类型的活性成分。所得结果表明，这种体外方法可作为一种有用的模型，用以重现植物提取物口服给药的某些特征。
