从血水草中分离得到的异黄酮和顺式查耳酮，具有平滑肌松弛活性。

Homoisoflavonoids and Chalcones Isolated from Haematoxylum campechianum L., with Spasmolytic Activity.

机构信息

Academics Division of Basic Sciences, University Juárez Autonomous of Tabasco, Highway Cunduacán-Jalpa Km. 0.5, Cunduacán Tabasco 86690, Mexico.

Southern Biomedical Research, Mexican Institute of Social Security, Argentina No. 1, Col. Centro, 62790 Xochitepec, Mexico.

出版信息

Molecules. 2017 Aug 24;22(9):1405. doi: 10.3390/molecules22091405.

DOI:10.3390/molecules22091405

PMID:28837100

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6151460/

Abstract

is a medicinal plant employed as an astringent to purify the blood and to treat stomach problems such as diarrhea and dysentery. A bio-guided chemical fractionation of the methanolic extract obtained from this plant allowed for the isolation of five compounds: two chalcones known as sappanchalcone (); 3-deoxysappanchalcone (); three homoisoflavonoids known as hematoxylol A (); 4--methylhematoxylol (); and, hematoxin (). The spasmolytic activity was determined in an in vitro model (electrically induced contractions of guinea pig ileum), and allowed to demonstrate that the methanolic extract (EC = 62.11 ± 3.23) fractions HcF7 (EC = 61.75 ± 3.55) and HcF9 (EC = 125.5 ± 10.65) and compounds (EC = 16.06 ± 2.15) and (EC = 25.37 ± 3.47) of present significant relaxing activity as compared to papaverine (EC = 20.08 ± 2.0) as a positive control.

摘要

是一种药用植物，用作收敛剂以净化血液并治疗腹泻和痢疾等胃部问题。从这种植物获得的甲醇提取物的生物导向化学分馏允许分离出五种化合物：两种查尔酮，称为 sappanchalcone (); 3-deoxysappanchalcone (); 三种同型异黄酮，称为hematoxylol A (); 4--methylhematoxylol (); 和，hematoxin (). 收缩活性在体外模型（豚鼠回肠的电诱导收缩）中进行了测定，并证明甲醇提取物（EC = 62.11 ± 3.23）部分 HcF7（EC = 61.75 ± 3.55）和 HcF9（EC = 125.5 ± 10.65）以及化合物（EC = 16.06 ± 2.15）和（EC = 25.37 ± 3.47）与阳性对照罂粟碱（EC = 20.08 ± 2.0）相比具有显著的舒张活性。