白细胞介素-2 复合物治疗可保护未致敏小鼠免受细菌和病毒感染。
IL-2 complex treatment can protect naive mice from bacterial and viral infection.
机构信息
Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology, Minneapolis, MN 55454, USA.
出版信息
J Immunol. 2010 Dec 1;185(11):6584-90. doi: 10.4049/jimmunol.1001215. Epub 2010 Oct 29.
Abstract
IL-2 complexes have substantial effects on the cellular immune system, and this approach is being explored for therapeutic application in infection and cancer. However, the impact of such treatments on subsequent encounter with pathogens has not been investigated. In this study, we report that naive mice treated with a short course of IL-2 complexes show enhanced protection from newly encountered bacterial and viral infections. IL-2 complex treatment expands both the NK and CD8 memory cell pool, including a recently described population of preexisting memory-phenotype T cells responsive to previously unencountered foreign Ags. Surprisingly, prolonged IL-2 complex treatment decreased CD8 T cell function and protective immunity. These data reveal the impact of cytokine complex treatment on the primary response to infection.
摘要
IL-2 复合物对细胞免疫系统有显著影响，这种方法正在被探索用于感染和癌症的治疗应用。然而，这种治疗方法对随后遇到病原体的影响尚未被研究。在这项研究中，我们报告说，用 IL-2 复合物进行短期治疗的幼稚小鼠显示出对新遇到的细菌和病毒感染的增强保护。IL-2 复合物治疗可扩增 NK 和 CD8 记忆细胞池，包括最近描述的一种对以前未遇到的外来抗原有反应的预先存在的记忆表型 T 细胞群体。令人惊讶的是，长期的 IL-2 复合物治疗会降低 CD8 T 细胞的功能和保护性免疫。这些数据揭示了细胞因子复合物治疗对感染初次反应的影响。
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