• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

白细胞介素-2 复合物治疗可保护未致敏小鼠免受细菌和病毒感染。

IL-2 complex treatment can protect naive mice from bacterial and viral infection.

机构信息

Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Center for Immunology, Minneapolis, MN 55454, USA.

出版信息

J Immunol. 2010 Dec 1;185(11):6584-90. doi: 10.4049/jimmunol.1001215. Epub 2010 Oct 29.

DOI:10.4049/jimmunol.1001215
PMID:21037095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3016939/
Abstract

IL-2 complexes have substantial effects on the cellular immune system, and this approach is being explored for therapeutic application in infection and cancer. However, the impact of such treatments on subsequent encounter with pathogens has not been investigated. In this study, we report that naive mice treated with a short course of IL-2 complexes show enhanced protection from newly encountered bacterial and viral infections. IL-2 complex treatment expands both the NK and CD8 memory cell pool, including a recently described population of preexisting memory-phenotype T cells responsive to previously unencountered foreign Ags. Surprisingly, prolonged IL-2 complex treatment decreased CD8 T cell function and protective immunity. These data reveal the impact of cytokine complex treatment on the primary response to infection.

摘要

IL-2 复合物对细胞免疫系统有显著影响，这种方法正在被探索用于感染和癌症的治疗应用。然而，这种治疗方法对随后遇到病原体的影响尚未被研究。在这项研究中，我们报告说，用 IL-2 复合物进行短期治疗的幼稚小鼠显示出对新遇到的细菌和病毒感染的增强保护。IL-2 复合物治疗可扩增 NK 和 CD8 记忆细胞池，包括最近描述的一种对以前未遇到的外来抗原有反应的预先存在的记忆表型 T 细胞群体。令人惊讶的是，长期的 IL-2 复合物治疗会降低 CD8 T 细胞的功能和保护性免疫。这些数据揭示了细胞因子复合物治疗对感染初次反应的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/bad86526dc1d/nihms-260434-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/23875c340803/nihms-260434-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/590459589926/nihms-260434-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/e2ffa6da7f01/nihms-260434-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/1606fa18d8e3/nihms-260434-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/3cd6f4a483cf/nihms-260434-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/bad86526dc1d/nihms-260434-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/23875c340803/nihms-260434-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/590459589926/nihms-260434-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/e2ffa6da7f01/nihms-260434-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/1606fa18d8e3/nihms-260434-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/3cd6f4a483cf/nihms-260434-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d48d/3016939/bad86526dc1d/nihms-260434-f0006.jpg

相似文献

1
IL-2 complex treatment can protect naive mice from bacterial and viral infection.白细胞介素-2 复合物治疗可保护未致敏小鼠免受细菌和病毒感染。
J Immunol. 2010 Dec 1;185(11):6584-90. doi: 10.4049/jimmunol.1001215. Epub 2010 Oct 29.
2
Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection.白细胞介素-7受体α的表达对于病毒感染期间记忆性CD8 T细胞的形成是必要的，但并不充分。
Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11730-5. doi: 10.1073/pnas.0705007104. Epub 2007 Jul 3.
3
Sustained and incomplete recovery of naive CD8+ T cell precursors after sepsis contributes to impaired CD8+ T cell responses to infection.脓毒症后幼稚 CD8+T 细胞前体的持续和不完全恢复导致对感染的 CD8+T 细胞反应受损。
J Immunol. 2013 Mar 1;190(5):1991-2000. doi: 10.4049/jimmunol.1202379. Epub 2013 Jan 25.
4
T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen.T 细胞内在因素有助于 CD8+T 细胞在缺乏抗原的情况下快速分泌 IFN-γ 的不同能力。
J Immunol. 2011 Feb 1;186(3):1703-12. doi: 10.4049/jimmunol.1001960. Epub 2010 Dec 29.
5
Innate inflammatory signals induced by various pathogens differentially dictate the IFN-I dependence of CD8 T cells for clonal expansion and memory formation.由各种病原体诱导的先天性炎症信号以不同方式决定了CD8 T细胞克隆扩增和记忆形成对I型干扰素（IFN-I）的依赖性。
J Immunol. 2006 Aug 1;177(3):1746-54. doi: 10.4049/jimmunol.177.3.1746.
6
Role of PKR and Type I IFNs in viral control during primary and secondary infection.PKR 和 I 型干扰素在原发性和继发性感染期间对病毒控制的作用。
PLoS Pathog. 2010 Jun 24;6(6):e1000966. doi: 10.1371/journal.ppat.1000966.
7
Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk.具有先天功能的记忆表型CD8 + T细胞在缺乏活性Itk的情况下选择性发育。
Eur J Immunol. 2007 Oct;37(10):2892-9. doi: 10.1002/eji.200737311.
8
CD4(+) T-cell dependence of primary CD8(+) T-cell response against vaccinia virus depends upon route of infection and viral dose.针对痘苗病毒的原发性CD8(+) T细胞反应对CD4(+) T细胞的依赖性取决于感染途径和病毒剂量。
Cell Mol Immunol. 2016 Jan;13(1):82-93. doi: 10.1038/cmi.2014.128. Epub 2014 Dec 29.
9
Manipulating the rate of memory CD8+ T cell generation after acute infection.调控急性感染后记忆性CD8+ T细胞的生成速率。
J Immunol. 2007 Jul 1;179(1):53-63. doi: 10.4049/jimmunol.179.1.53.
10
Coadministration of polyinosinic:polycytidylic acid and immunostimulatory complexes modifies antigen processing in dendritic cell subsets and enhances HIV gag-specific T cell immunity.聚肌苷酸-聚胞苷酸与免疫刺激复合物联合给药可调节树突状细胞亚群中的抗原加工，并增强 HIV gag 特异性 T 细胞免疫。
J Immunol. 2013 Nov 15;191(10):5085-96. doi: 10.4049/jimmunol.1301730. Epub 2013 Oct 2.

引用本文的文献

1
The Predictive Significance of Interleukin-2 Receptor in Patients with Hepatocellular Carcinoma.白细胞介素-2受体在肝细胞癌患者中的预测意义
J Hepatocell Carcinoma. 2025 Aug 22;12:1893-1904. doi: 10.2147/JHC.S536877. eCollection 2025.
2
Immune Signatures Distinguish Pure and Mixed Sepsis in Critical COVID-19: A Retrospective Cohort Study.免疫特征区分重症COVID-19中的单纯性和混合性脓毒症：一项回顾性队列研究
J Inflamm Res. 2025 Aug 14;18:11139-11153. doi: 10.2147/JIR.S531962. eCollection 2025.
3
A hypomorphic Il2rb mutant mouse model recapitulates and reveals mechanisms of human T cell immune dysregulation in IL-2Rβ deficiency.一种低表达的Il2rb突变小鼠模型概括并揭示了IL-2Rβ缺陷时人类T细胞免疫失调的机制。
Cell Rep. 2025 Jul 22;44(7):115902. doi: 10.1016/j.celrep.2025.115902. Epub 2025 Jun 25.
4
Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells.用 S4B6 IL-2 复合物治疗小鼠可通过非 CD4 免疫细胞产生依赖于 IL-12 和 IL-18 的 IFN-γ来预防致死性弓形虫病。
Sci Rep. 2020 Aug 4;10(1):13115. doi: 10.1038/s41598-020-70102-1.
5
Contributions of natural killer cells to the immune response against Plasmodium.自然杀伤细胞对针对疟原虫的免疫反应的贡献。
Malar J. 2019 Sep 18;18(1):321. doi: 10.1186/s12936-019-2953-1.
6
Antitumor Effects and Related Mechanisms of Ethyl Acetate Extracts of L.L. 的乙酸乙酯提取物的抗肿瘤作用及相关机制
Front Oncol. 2019 Jul 4;9:578. doi: 10.3389/fonc.2019.00578. eCollection 2019.
7
Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.多微生物脓毒症通过减少 NK 细胞内在受体介导的对病毒配体或感染的效应反应来影响 NK 细胞介导的免疫。
PLoS Pathog. 2018 Oct 31;14(10):e1007405. doi: 10.1371/journal.ppat.1007405. eCollection 2018 Oct.
8
Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells.白细胞介素-15 复合物治疗通过诱导产生白细胞介素-10 的自然杀伤细胞来保护小鼠免受脑型疟疾。
Immunity. 2018 Apr 17;48(4):760-772.e4. doi: 10.1016/j.immuni.2018.03.012. Epub 2018 Apr 3.
9
IL-2 and Beyond in Cancer Immunotherapy.白细胞介素-2及癌症免疫疗法的新进展
J Interferon Cytokine Res. 2018 Feb;38(2):45-68. doi: 10.1089/jir.2017.0101.
10
Cutting Edge: The Aging Immune System Reveals the Biological Impact of Direct Antigen Presentation on CD8 T Cell Responses.前沿：衰老的免疫系统揭示了直接抗原呈递对CD8 T细胞反应的生物学影响。
J Immunol. 2017 Jul 15;199(2):403-407. doi: 10.4049/jimmunol.1700625. Epub 2017 Jun 14.

本文引用的文献

1
Lessons learned from natural infection: focusing on the design of protective T cell vaccines for HIV/AIDS.从自然感染中吸取的教训：聚焦于 HIV/AIDS 保护性 T 细胞疫苗的设计。
Trends Immunol. 2010 Mar;31(3):120-30. doi: 10.1016/j.it.2009.12.003. Epub 2010 Jan 19.
2
In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy.作为癌症免疫治疗的新方法，白细胞介素-2与抗白细胞介素-2单克隆抗体复合物驱动的活化初始CD8+ T细胞和自然杀伤细胞的体内扩增。
J Immunol. 2009 Oct 15;183(8):4904-12. doi: 10.4049/jimmunol.0900284.
3
Cutting edge: IL-2 immune complexes as a therapy for persistent virus infection.前沿：白细胞介素-2免疫复合物作为持续性病毒感染的一种治疗方法。
J Immunol. 2009 Apr 15;182(8):4512-5. doi: 10.4049/jimmunol.0804175.
4
The diversity of costimulatory and inhibitory receptor pathways and the regulation of antiviral T cell responses.共刺激和抑制性受体途径的多样性以及抗病毒T细胞反应的调节。
Curr Opin Immunol. 2009 Apr;21(2):179-86. doi: 10.1016/j.coi.2009.01.010. Epub 2009 Mar 4.
5
The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion.未免疫小鼠中的抗原特异性CD8 + T细胞库包括带有稳态扩增标记的记忆表型细胞。
J Exp Med. 2009 Feb 16;206(2):435-48. doi: 10.1084/jem.20081829. Epub 2009 Feb 2.
6
Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy.靶向先天免疫和适应性免疫的佐剂协同作用以增强肿瘤免疫治疗。
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16683-8. doi: 10.1073/pnas.0805054105. Epub 2008 Oct 20.
7
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.在免疫反应收缩阶段，白细胞介素-7和白细胞介素-15对CD8 + T细胞亚群的调节作用存在差异。
Blood. 2008 Nov 1;112(9):3704-12. doi: 10.1182/blood-2008-06-160945. Epub 2008 Aug 8.
8
CD8+ T cell efficacy in vaccination and disease.CD8+ T细胞在疫苗接种和疾病中的功效。
Nat Med. 2008 Jun;14(6):623-8. doi: 10.1038/nm.f.1774.
9
Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation.白细胞介素-2与抗白细胞介素-2单克隆抗体联合治疗通过激活自然杀伤细胞减少肿瘤转移。
Int Immunol. 2008 Jun;20(6):783-9. doi: 10.1093/intimm/dxn036. Epub 2008 Apr 30.
10
IL-2/anti-IL-2 antibody complex enhances vaccine-mediated antigen-specific CD8+ T cell responses and increases the ratio of effector/memory CD8+ T cells to regulatory T cells.白细胞介素-2/抗白细胞介素-2抗体复合物增强疫苗介导的抗原特异性CD8+ T细胞反应，并增加效应/记忆性CD8+ T细胞与调节性T细胞的比例。
J Immunol. 2008 Apr 1;180(7):5118-29. doi: 10.4049/jimmunol.180.7.5118.