Buckler J M H, Green M
Department of Paediatrics and Child Health, University of Leeds, Leeds, UK.
Ann Hum Biol. 2011 May;38(3):271-80. doi: 10.3109/03014460.2010.526963. Epub 2010 Nov 1.
Few studies have compared the growth of a twin with its co-twin and particularly in relation to birth weight discordance.
The study investigated how the degree of birth weight discordance affected subsequent growth.
Birth weight discordance of 762 twin pairs was determined. Subsequent weight, height and occipital-frontal head circumference (OFC) measurements were obtained between the ages of 2-9 years. Corresponding standard deviations scores (SDS) were analysed according to birth weight discordance, sex and zygosity. Weight status was taken into account by assigning twins into sub-groups according to whether they were the heavier twin at birth and remained heavier, became the lighter of the twin pair or had the same weight, for subsequent measurements.
The degree of birth weight discordance had little effect on subsequent growth except in monozygotic (MZ) twins with >20% discordance. Severe low birth weight ( < 1.95 kg) is more significant in suppressing subsequent growth than the degree of discordance per se. A surprisingly high proportion of twins reversed their weight status when reviewed at an older age.
很少有研究比较双胞胎与其同胞的生长情况，特别是与出生体重不一致相关的情况。
本研究调查出生体重不一致程度如何影响后续生长。
确定了762对双胞胎的出生体重不一致情况。在2至9岁之间获取了后续的体重、身高和枕额头围（OFC）测量值。根据出生体重不一致、性别和同卵性分析相应的标准差分数（SDS）。通过根据双胞胎在出生时是否较重并一直保持较重、成为双胞胎中较轻的一方或体重相同，将双胞胎分为亚组，来考虑体重状况，以便进行后续测量。
出生体重不一致程度对后续生长影响不大，除非是不一致程度>20%的单卵双胞胎（MZ）。严重低出生体重（<1.95千克）在抑制后续生长方面比不一致程度本身更显著。令人惊讶的是，很大比例的双胞胎在年龄较大时复查时体重状况发生了逆转。
