Department of Orthopedics, University Medical Center, Utrecht, The Netherlands.
Tissue Eng Part B Rev. 2010 Dec;16(6):551-66. doi: 10.1089/ten.teb.2010.0176. Epub 2010 Nov 1.
Bone regeneration is a complex process regulated by a large number of bioactive molecules. Many growth factors and cytokines involved in the natural process of bone healing have been identified and tested as potential therapeutic candidates to enhance the regeneration process. Although many of these studies show an enhancement of the bone regeneration process by a single drug therapy, in vivo bone regeneration is the result of a complex interplay between the applied growth factor and various endogenous produced growth factors. To investigate these growth factor interactions, various studies have investigated the effect of growth factor combinations on bone regeneration. This review provides an overview of the growth factor and cytokine combinations tested in translational bone regeneration studies and shows that their interaction may result in an enhancement or inhibition of bone formation.
骨再生是一个由大量生物活性分子调节的复杂过程。许多参与骨愈合自然过程的生长因子和细胞因子已被鉴定并测试为潜在的治疗候选物，以增强再生过程。尽管这些研究中的许多都显示出单一药物治疗可增强骨再生过程，但体内骨再生是应用生长因子与各种内源性产生的生长因子之间复杂相互作用的结果。为了研究这些生长因子的相互作用，许多研究已经研究了生长因子组合对骨再生的影响。本综述概述了在转化骨再生研究中测试的生长因子和细胞因子组合，并表明它们的相互作用可能导致骨形成的增强或抑制。
