Hariawan B S, Miatmoko A, Anjani Q K, Annuryanti F, Kamadjaja D B, Nurkanto A, Hariyadi D M
Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C UNAIR Mulyorejo, Surabaya, Indonesia.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C UNAIR Mulyorejo, Surabaya, Indonesia.
Braz J Med Biol Res. 2025 Feb 3;58:e14057. doi: 10.1590/1414-431X2024e14057. eCollection 2025.
Bone fractures must undergo a complex healing process involving intricate cellular and molecular mechanisms. They require a suitable biological environment to restore skeletal stability and resolve inflammation. Scaffolds play a vital role in bone regeneration, thus reducing disease burden. Autologous bone graft represents the gold standard of therapy. However, its application is limited due to various reasons. Nanotechnology, in the form of nanomaterials and nano-drug delivery systems, has been proven to increase the potency of active substances in mimicking extracellular matrix (ECM), thereby providing physical support benefits and enhancing therapeutic effectiveness. Various materials, including protein, metal oxide, hydroxyapatite, and silica are modified with nanoparticle technology for the purposes of tissue regeneration therapy. Moreover, the properties of nanomaterials such as size, seta potential, and surface properties will affect their effectiveness in bone regeneration therapy. This review provides insights that deepen the knowledge of the manufacturing and application of nanomaterials as a therapeutic agent for bone regeneration.
骨折必须经历一个复杂的愈合过程，涉及错综复杂的细胞和分子机制。它们需要一个合适的生物环境来恢复骨骼稳定性并消除炎症。支架在骨再生中起着至关重要的作用，从而减轻疾病负担。自体骨移植是治疗的金标准。然而，由于各种原因，其应用受到限制。纳米技术，以纳米材料和纳米药物递送系统的形式，已被证明可以提高活性物质模拟细胞外基质（ECM）的能力，从而提供物理支持益处并提高治疗效果。为了组织再生治疗的目的，包括蛋白质、金属氧化物、羟基磷灰石和二氧化硅在内的各种材料都用纳米颗粒技术进行了改性。此外，纳米材料的尺寸、zeta电位和表面性质等特性会影响它们在骨再生治疗中的有效性。本综述提供了一些见解，加深了对纳米材料作为骨再生治疗剂的制造和应用的认识。
