Department of Surgery, Division of Orthopaeadics, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Injury. 2011 Jun;42(6):574-9. doi: 10.1016/j.injury.2011.03.034. Epub 2011 Apr 13.
A large body of research has investigated the use of growth factors for bone regeneration, as a potential alternative to autogenous bone grafting. The bone morphogenetic proteins (BMPs) represent the most extensively investigated growth factors to date, as potential therapeutic agents for bone regeneration. Despite decades of research, the ideal growth factor or combination of growth factors for bone regeneration remains undefined. This article reviews the current available evidence for the application of growth factors for bone regeneration, with a focus on the clinical evidence for BMP use. Emerging pre-clinical and clinical evidence for growth factors other than the BMPs is also discussed.
大量研究调查了生长因子在骨再生中的应用，作为自体骨移植物的潜在替代物。骨形态发生蛋白（BMPs）是迄今为止研究最广泛的生长因子，作为骨再生的潜在治疗剂。尽管经过了几十年的研究，但理想的生长因子或生长因子组合仍未确定。本文综述了目前关于生长因子在骨再生中的应用的现有证据，重点是 BMP 应用的临床证据。还讨论了除 BMP 以外的生长因子的新兴临床前和临床证据。
