Laboratory of Institut de Recerca i Tecnologia Agroalimentàries (IRTA) - Institut de Ciències del Mar, Consejo Superior de Investigaciones Científicas (CSIC), Passeig marítim 37-49, 08003 Barcelona, Spain.
J Fish Biol. 2010 Oct;77(5):1045-70. doi: 10.1111/j.1095-8649.2010.02695.x.
Flatfishes are a group of teleosts of high commercial and environmental interest, whose biology is still poorly understood. The recent rapid development of different 'omic' technologies is, however, enhancing the knowledge of the complex genetic control underlying different physiological processes of flatfishes. This review describes the different functional genomic approaches and resources currently available for flatfish research and summarizes different areas where microarray-based gene expression analysis has been applied. The increase in genome sequencing data has also allowed the construction of genetic linkage maps in different flatfish species; these maps are invaluable for investigating genome organization and identifying genetic traits of commercial interest. Despite the significant progress in this field, the genomic resources currently available for flatfish are still scarce. Further intensive research should be carried out to develop larger genomic sequence databases, high-density microarrays and, more detailed, complete linkage maps, using second-generation sequencing platforms. These tools will be crucial for further expanding the knowledge of flatfish physiology, and it is predicted that they will have important implications for wild fish population management, improved fish welfare and increased productivity in aquaculture.
比目鱼是一类具有重要商业和环境价值的硬骨鱼类，但其生物学特性仍知之甚少。然而，近年来不同“组学”技术的快速发展，正在增强我们对不同生理过程背后复杂遗传控制的认识。本综述描述了当前用于比目鱼研究的不同功能基因组方法和资源，并总结了基于微阵列的基因表达分析已应用的不同领域。基因组测序数据的增加也使得在不同比目鱼物种中构建了遗传连锁图谱；这些图谱对于研究基因组组织和鉴定具有商业价值的遗传特征非常有价值。尽管在这一领域取得了重大进展，但目前比目鱼可用的基因组资源仍然稀缺。应进一步开展深入研究，以开发更大的基因组序列数据库、高密度微阵列和更详细、完整的连锁图谱，使用第二代测序平台。这些工具对于进一步扩展比目鱼生理学知识至关重要，预计它们将对野生鱼类种群管理、鱼类福利改善和水产养殖生产力提高产生重要影响。
