U.S. Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Research Triangle Park, NC, USA.
Risk Anal. 2011 Apr;31(4):592-608. doi: 10.1111/j.1539-6924.2010.01524.x. Epub 2010 Oct 29.
Daily soil/dust ingestion rates typically used in exposure and risk assessments are based on tracer element studies, which have a number of limitations and do not separate contributions from soil and dust. This article presents an alternate approach of modeling soil and dust ingestion via hand and object mouthing of children, using EPA's SHEDS model. Results for children 3 to <6 years old show that mean and 95th percentile total ingestion of soil and dust values are 68 and 224 mg/day, respectively; mean from soil ingestion, hand-to-mouth dust ingestion, and object-to-mouth dust ingestion are 41 mg/day, 20 mg/day, and 7 mg/day, respectively. In general, hand-to-mouth soil ingestion was the most important pathway, followed by hand-to-mouth dust ingestion, then object-to-mouth dust ingestion. The variability results are most sensitive to inputs on surface loadings, soil-skin adherence, hand mouthing frequency, and hand washing frequency. The predicted total soil and dust ingestion fits a lognormal distribution with geometric mean = 35.7 and geometric standard deviation = 3.3. There are two uncertainty distributions, one below the 20th percentile and the other above. Modeled uncertainties ranged within a factor of 3-30. Mean modeled estimates for soil and dust ingestion are consistent with past information but lower than the central values recommended in the 2008 EPA Child-Specific Exposure Factors Handbook. This new modeling approach, which predicts soil and dust ingestion by pathway, source type, population group, geographic location, and other factors, offers a better characterization of exposures relevant to health risk assessments as compared to using a single value.
日常土壤/灰尘摄入量通常用于暴露和风险评估,基于示踪元素研究,这些研究有许多局限性,无法区分土壤和灰尘的贡献。本文提出了一种替代方法,通过儿童的手和物体接触来模拟土壤和灰尘的摄入,使用 EPA 的 SHEDS 模型。对于 3 至<6 岁的儿童,结果表明,土壤和灰尘总摄入量的平均值和 95 百分位数分别为 68 和 224 毫克/天;分别来自土壤摄入、手到口灰尘摄入和物体到口灰尘摄入的平均值为 41 毫克/天、20 毫克/天和 7 毫克/天。总的来说,手到口土壤摄入是最重要的途径,其次是手到口灰尘摄入,然后是物体到口灰尘摄入。结果的可变性最敏感于表面负荷、土壤-皮肤附着、手接触频率和洗手频率的输入。预测的总土壤和灰尘摄入量符合对数正态分布,几何平均值=35.7,几何标准差=3.3。有两个不确定性分布,一个低于第 20 百分位数,另一个高于第 20 百分位数。模型化的不确定性范围在 3 到 30 倍之间。土壤和灰尘摄入量的模型化估计平均值与过去的信息一致,但低于 2008 年 EPA 儿童特定暴露因素手册中推荐的中位数。这种新的建模方法通过途径、源类型、人群组、地理位置和其他因素预测土壤和灰尘的摄入,与使用单一值相比,更好地描述了与健康风险评估相关的暴露情况。