Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong.
J Gastroenterol Hepatol. 2010 Nov;25(11):1726-31. doi: 10.1111/j.1440-1746.2010.06437.x.
In clinical practice, it is important to assess the severity of liver fibrosis in patients with various liver diseases to determine the prognosis, decide treatment, and monitor disease progression and response to treatment. Liver biopsy is limited by its invasiveness and patient acceptability. The development of transient elastography provides clinicians with a non-invasive, accurate, and reproducible tool to estimate liver fibrosis. The technique has been validated among many liver diseases and requires only simple training. Due to its non-invasive nature and ease of use, transient elastography can be used repeatedly on patients, and is optimal for large-scale epidemiological studies, in which stable patients with no indication for liver biopsy can also be included. However, falsely-high liver stiffness measurements might occur during acute hepatitis, extrahepatic cholestasis, congestive heart failure, and amyloidosis. Failed acquisition is also common in obese patients. The development of S and XL probes might cater for different population groups, but calibration in patients with liver biopsy is essential.
在临床实践中，评估各种肝病患者肝纤维化的严重程度非常重要，这有助于判断预后、决定治疗方案，并监测疾病进展和治疗反应。肝活检具有侵袭性，且患者接受度较差。瞬时弹性成像技术的出现为临床医生提供了一种非侵入性、准确且可重复的工具来评估肝纤维化。该技术已在多种肝病中得到验证，且仅需要简单的培训。由于其非侵入性和易用性，瞬时弹性成像可在患者身上重复使用，非常适合大规模的流行病学研究，包括无肝活检指征的稳定患者也可纳入研究。然而，在急性肝炎、肝外胆汁淤积、充血性心力衰竭和淀粉样变性期间，可能会出现假性高肝硬度测量值。在肥胖患者中，也常出现获取失败的情况。S 和 XL 探头的开发可能适用于不同的人群，但在有肝活检的患者中进行校准至关重要。
