利用超声生物显微镜图像对皮肤细胞癌进行的离体研究。

Study of cutaneous cell carcinomas ex vivo using ultrasound biomicroscopic images.

机构信息

Biomedical Engineering Program, Center of Technology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

出版信息

Skin Res Technol. 2010 Nov;16(4):422-7. doi: 10.1111/j.1600-0846.2010.00448.x.

DOI:10.1111/j.1600-0846.2010.00448.x

PMID:21039907

Abstract

BACKGROUND

The ultrasound biomicroscopy (UBM) technique generates high-resolution echographic images using acoustic frequencies between 20 and 200 MHz. In dermatology, it enables non-invasive visualization of cutaneous structures. In this sense, several studies are being conducted for the measurement of cutaneous tumor sizes and for the evaluation of their response to therapeutic procedures. The present work was conducted to analyze the ability of UBM to identify diverse histological structures associated with cutaneous carcinomas ex vivo regarding the evaluation of the technique as a diagnostic tool that could, eventually, improve the patient's healthcare protocol.

METHODS

Ex vivo human tissue samples, corresponding to basal cell carcinoma and squamous cell carcinoma cases, were studied. The ultrasonic system operated with a center frequency of 45MHz and the histological structures were identified by comparison with the light microscopy images.

RESULTS

The histological components present in the tumors were identified by variations in the echogenicity level for several of the studied cases and particular characteristics were observed for the different tumor types.

CONCLUSION

The possibility of differentiating the histological components associated with cutaneous carcinomas indicates the potential use of UBM for diagnostic applications. However, a larger number of specimens must be studied.

摘要

背景

超声生物显微镜（UBM）技术使用 20 至 200 MHz 之间的声波频率生成高分辨率的超声图像。在皮肤科中，它可以实现对皮肤结构的非侵入性可视化。在这种情况下，正在进行多项研究来测量皮肤肿瘤的大小，并评估其对治疗程序的反应。本研究旨在分析 UBM 识别与皮肤癌相关的不同组织学结构的能力，以评估该技术是否可作为一种诊断工具，最终改善患者的医疗保健方案。