Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
Clin Microbiol Infect. 2011 Aug;17(8):1226-31. doi: 10.1111/j.1469-0691.2010.03388.x. Epub 2010 Dec 6.
Human infections caused by Weissella confusa are rarely reported. Ten patients with bacteraemia caused by W. confusa who were treated at a tertiary-care hospital in Taiwan during 1997-2007 were studied. All isolates were initially misidentified as various Lactobacillus and Leuconostoc species by two commercial automated identification methods, and were confirmed to be W. confusa by 16S rRNA sequencing analysis. MICs of these isolates for ten antimicrobial agents were determined by the agar dilution method. The characteristics of these patients included underlying malignancy (n = 4), presence of a central catheter (n = 6), surgery within the previous 3 months (n = 4) and concomitant polymicrobial bacteraemia (n = 5, 50%). Mortality was directly attributed to bacteraemia in two patients. All isolates exhibited high trimethoprim-sulphamethoxazole and ceftazidime MICs (≥ 128 mg/L) and were inhibited by linezolid, daptomycin, ceftobiprole and tigecycline at 4, 0.12, 2 and 0.12 mg/L, respectively. In conclusion, W. confusa should be included in the list of organisms causing bacteraemia in immunocompromised hosts. Novel antibiotics, including daptomycin, moxifloxacin, doripenem and tigecycline, exert good activity against W. confusa.
人感染魏斯氏菌属很少报道。1997-2007 年，在台湾一家三级医院治疗的 10 例魏斯氏菌属引起的菌血症患者进行了研究。所有分离株最初均被两种商业自动鉴定方法误鉴定为各种乳杆菌属和肠球菌属，通过 16S rRNA 测序分析证实为魏斯氏菌属。采用琼脂稀释法测定这些分离株对 10 种抗菌药物的 MIC。这些患者的特征包括基础恶性肿瘤（n = 4）、中心导管存在（n = 6）、在过去 3 个月内进行手术（n = 4）和同时伴有混合菌血症（n = 5，50%）。两名患者的死亡直接归因于菌血症。所有分离株均表现出高磺胺甲恶唑/甲氧苄啶和头孢他啶 MIC（≥ 128 mg/L），并被利奈唑胺、达托霉素、头孢比肟和替加环素抑制，MIC 值分别为 4、0.12、2 和 0.12 mg/L。总之，魏斯氏菌属应列入免疫功能低下宿主菌血症的病原体名单。新型抗生素，包括达托霉素、莫西沙星、多利培南和替加环素，对魏斯氏菌属具有良好的活性。
