Hospital Neuropsiquiátrico Braulio A. Moyano, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina.
Bipolar Disord. 2010 Nov;12(7):702-6. doi: 10.1111/j.1399-5618.2010.00864.x.
Antidepressant-induced mania (AIM) has been associated with the serotonin-transporter-linked promoter region (5-HTTLPR) polymorphism in some studies but not in others. We conducted a meta-analysis of those studies and other studies of genetic predictors of AIM.
MEDLINE-based searches of genetic studies of AIM were conducted, and a meta-analysis of six studies of 5-HTTLPR was performed. Other polymorphisms were insufficiently studied to allow for meta-analysis.
There was an association of the short (s) variant of 5-HTTLPR and AIM [risk ratio (RR) = 1.35, 95% confidence interval (CI): 1.04-1.76, p=0.02]. There was a higher frequency of s carriers (sl and ss genotypes) in those who developed AIM [RR = 1.38, 95% CI: 0.98-1.93), p=0.06].
The 5-HTTLPR polymorphism appears to have a moderate effect size association with AIM in patients with bipolar disorder.
一些研究表明，抗抑郁药诱发的躁狂（AIM）与 5-羟色胺转运体启动子区域（5-HTTLPR）多态性有关，但其他研究并未发现这种关联。我们对这些研究以及其他研究 AIM 的遗传预测因子进行了荟萃分析。
我们进行了基于 MEDLINE 的 AIM 遗传研究的搜索，并对 5-HTTLPR 的六项研究进行了荟萃分析。其他多态性研究不足，无法进行荟萃分析。
5-HTTLPR 的短（s）变体与 AIM 之间存在关联[风险比（RR）=1.35，95%置信区间（CI）：1.04-1.76，p=0.02]。在发生 AIM 的患者中，s 携带者（sl 和 ss 基因型）的频率更高[RR=1.38，95% CI：0.98-1.93），p=0.06]。
5-HTTLPR 多态性似乎与双相情感障碍患者的 AIM 具有中等效应大小的关联。
