Halabi Ramzi, Yusuff Khairatun, Park Clara, DeShaw Alexandra, Gonzalez-Torres Christina, Husain Muhammad I, O'Donovan Claire, Alda Martin, Mulsant Benoit H, Ortiz Abigail
Campbell Family Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.
Bipolar Disord. 2024 Dec;26(8):810-819. doi: 10.1111/bdi.13504. Epub 2024 Sep 27.
The use of antidepressants in bipolar disorder (BD) remains contentious, in part due to the risk of antidepressant-induced mania (AIM). However, there is no information on the architecture of mood regulation in patients who have experienced AIM. We compared the architecture of mood regulation in euthymic patients with and without a history of AIM.
Eighty-four euthymic participants were included. Participants rated their mood, anxiety and energy levels daily using an electronic (e-) visual analog scale, for a mean (SD) of 280.8(151.4) days. We analyzed their multivariate time series by computing each variable's auto-correlation, inter-variable cross-correlation, and composite multiscale entropy of mood, anxiety, and energy. Then, we compared the data features of participants with a history of AIM and those without AIM, using analysis of covariance, controlling for age, sex, and current treatment.
Based on 18,103 daily observations, participants with AIM showed significantly stronger day-to-day auto-correlation and cross-correlation for mood, anxiety, and energy than those without AIM. The highest cross-correlation in participants with AIM was between mood and energy within the same day (median (IQR), 0.58 (0.27)). The strongest negative cross-correlation in participants with AIM was between mood and anxiety series within the same day (median (IQR), -0.52 (0.34)).
Patients with a history of AIM have a different underlying mood architecture compared to those without AIM. Their mood, anxiety and energy stay the same from day-to-day; and their anxiety is negatively correlated with their mood.
在双相情感障碍（BD）中使用抗抑郁药仍存在争议，部分原因是存在抗抑郁药诱发躁狂（AIM）的风险。然而，对于经历过AIM的患者，情绪调节的结构尚无相关信息。我们比较了有和没有AIM病史的心境正常患者的情绪调节结构。
纳入84名心境正常的参与者。参与者每天使用电子视觉模拟量表对其情绪、焦虑和精力水平进行评分，平均（标准差）为280.8（151.4）天。我们通过计算每个变量的自相关、变量间交叉相关以及情绪、焦虑和精力的复合多尺度熵来分析他们的多变量时间序列。然后，我们使用协方差分析，在控制年龄、性别和当前治疗的情况下，比较有AIM病史的参与者和没有AIM病史的参与者的数据特征。
基于18103条每日观察数据，有AIM病史的参与者在情绪、焦虑和精力方面的日常自相关和交叉相关明显强于没有AIM病史的参与者。有AIM病史的参与者中，同一天内情绪和精力之间的交叉相关性最高（中位数（四分位间距），0.58（0.27））。有AIM病史的参与者中，同一天内情绪和焦虑序列之间的负交叉相关性最强（中位数（四分位间距），-0.52（0.34））。
有AIM病史的患者与没有AIM病史的患者相比，其潜在的情绪结构不同。他们的情绪、焦虑和精力日复一日保持不变；并且他们的焦虑与情绪呈负相关。
