Nepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology, Kathmandu, Nepal.
Clin Exp Ophthalmol. 2011 Mar;39(2):126-34. doi: 10.1111/j.1442-9071.2010.02429.x. Epub 2010 Dec 16.
To describe the methodology and baseline data of a population-based study designed to determine the prevalence of glaucoma and to study the risk factors for glaucoma development in a Nepali population.
Population-based cross-sectional study.
Subjects 40 years and above residing in Bhaktapur District.
Power calculations suggest that a sample size of 4758 is required. Thirty clusters were randomly selected from the 2 municipalities and 16 Village Development Committees of Bhaktapur District in Nepal. A door-to-door census was conducted in the selected clusters to identify citizens 40 years of age and older. Demographic details were collected and a structured interview, regarding awareness for cataract and glaucoma was taken. All individuals fulfilling the eligibility criteria were recruited and referred to the Tilganga Institute of Ophthalmology in Kathmandu for a detailed clinical examination including glaucoma diagnostic procedures. Peripheral blood samples were taken to facilitate future genetic analysis.
Prevalence of glaucoma, risk factors and genetic screening.
A total of 4800 people were selected. The mean age of participants was 55.4 ± 12.3 years (range: 40-99) and 51.8% were female. In total, 64.8% of our cohort was aged less than 59 years and 60.5% were illiterate. Among the various ethnic races, 69.7% belonged to the Newar ethnic group.
This study will determine the prevalence of glaucoma and allow for an increased understanding of the risk factors for glaucoma development in this region.
描述一项基于人群的研究的方法和基线数据，该研究旨在确定尼泊尔人群中青光眼的患病率，并研究青光眼发展的危险因素。
基于人群的横断面研究。
居住在巴克塔普尔地区的 40 岁及以上的人群。
根据计算，我们需要 4758 名样本量。从尼泊尔巴克塔普尔地区的 2 个市和 16 个村发展委员会中随机选择了 30 个集群。在选定的集群中进行了逐户人口普查，以确定 40 岁及以上的公民。收集人口统计学详细信息，并进行有关白内障和青光眼意识的结构化访谈。符合入选标准的所有个体均被招募，并转介到加德满都的 Tilganga 眼科研究所进行详细的临床检查，包括青光眼诊断程序。采集外周血样，以便进行未来的遗传分析。
青光眼的患病率、危险因素和遗传筛查。
共选择了 4800 人。参与者的平均年龄为 55.4 ± 12.3 岁（范围：40-99），51.8%为女性。我们的队列中共有 64.8%的人年龄小于 59 岁，60.5%的人是文盲。在各种族中，69.7%属于纽瓦族。
这项研究将确定青光眼的患病率，并使我们对该地区青光眼发展的危险因素有更深入的了解。
